Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Cell Mol Biol Lett. 2022 Apr 9;27(1):33. doi: 10.1186/s11658-022-00332-w.
Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid tumors is the use of tumor-targeting peptides to deliver drugs or active agents selectively.
Introducing beneficial therapeutic approaches, such as therapeutic peptides and their varied methods of action against tumor cells, can aid researchers in the discovery of novel peptides for cancer treatment. The biomedical applications of therapeutic peptides are highly interesting. These peptides, owing to their high selectivity, specificity, small dimensions, high biocompatibility, and easy modification, provide good opportunities for targeted drug delivery. In recent years, peptides have shown considerable promise as therapeutics or targeting ligands in cancer research and nanotechnology.
This study reviews a variety of therapeutic peptides and targeting ligands in cancer therapy. Initially, three types of tumor-homing and cell-penetrating peptides (CPPs) are described, and then their applications in breast, glioma, colorectal, and melanoma cancer research are discussed.
如今，手术、放疗和化疗等传统医学治疗方法无法治愈所有类型的癌症。一种有前途的治疗实体瘤的方法是使用肿瘤靶向肽有选择性地输送药物或活性剂。
引入有益的治疗方法，如治疗肽及其对肿瘤细胞的各种作用方式，可以帮助研究人员发现用于癌症治疗的新型肽。治疗肽的生物医学应用非常有趣。由于这些肽具有高选择性、特异性、小尺寸、高生物相容性和易于修饰等特点，为靶向药物输送提供了良好的机会。近年来，肽在癌症研究和纳米技术中作为治疗剂或靶向配体显示出了很大的潜力。
本研究综述了癌症治疗中的多种治疗肽和靶向配体。首先描述了三种肿瘤归巢和细胞穿透肽（CPP），然后讨论了它们在乳腺癌、神经胶质瘤、结直肠癌和黑色素瘤研究中的应用。
