Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Beijing, 100730, China.
Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Orphanet J Rare Dis. 2020 Nov 18;15(1):325. doi: 10.1186/s13023-020-01610-6.
Choriocarcinoma is a rare malignant neoplasm, which is classified as either gestational choriocarcinoma or nongestational choriocarcinoma. The purpose of this study was to examine the clinical characteristics of Chinese female nongestational choriocarcinoma patients and discuss our experience in treating this rare disease.
We conducted a single-center retrospective study on a sample of 37 nongestational choriocarcinoma patients who were diagnosed and treated at Peking Union Medical College Hospital from March 1982 to March 2020. Their demographic, clinical, laboratory, and therapeutic data were collected. Detailed information was available for all 37 individuals in our sample. The primary lesions included 34 in the ovaries, 2 in the pituitary and 1 in the stomach. The median age of onset was 22 years, and the median follow-up period spanned 41 months. The lungs (40.5%) were the most commonly observed metastatic site. All subjects were treated with surgery and multidrug chemotherapies, and a median of 4.0 courses was required to achieve complete remission. The overall complete response rate, relapse rate, and 3-year and 5-year survival rates were 81.1%, 16.7%, 80.0%, and 75.5%, respectively.
Nongestational choriocarcinoma can be managed well using surgery and multidrug chemotherapies, but the overall outcome of nongestational choriocarcinoma is still worse than that of gestational choriocarcinoma. Mixed nongestational choriocarcinoma seems to have similar therapeutic outcomes as pure tumors.
绒癌是一种罕见的恶性肿瘤，分为妊娠性绒癌和非妊娠性绒癌。本研究旨在探讨中国女性非妊娠性绒癌患者的临床特征，并总结治疗经验。
我们对 1982 年 3 月至 2020 年 3 月期间在北京协和医院诊断和治疗的 37 例非妊娠性绒癌患者进行了单中心回顾性研究。收集了患者的人口统计学、临床、实验室和治疗数据。我们的样本中所有 37 例患者的详细信息均可用。原发灶包括卵巢 34 例、垂体 2 例、胃 1 例。发病中位年龄为 22 岁，中位随访时间为 41 个月。最常见的转移部位是肺部（40.5%）。所有患者均接受手术和多药化疗，中位化疗 4.0 个疗程达到完全缓解。总的完全缓解率、复发率、3 年和 5 年生存率分别为 81.1%、16.7%、80.0%和 75.5%。
手术联合多药化疗可以较好地治疗非妊娠性绒癌，但非妊娠性绒癌的总体预后仍不如妊娠性绒癌。混合性非妊娠性绒癌的治疗效果似乎与单纯性肿瘤相似。
