Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Int J Gynecol Cancer. 2010 Feb;20(2):299-302. doi: 10.1111/IGC.0b013e3181cc2526.
The objective of the study was to investigate the clinical characters, diagnosis, treatment, and prognosis of nongestational ovarian choriocarcinoma.
A retrospective analysis was done on 21 patients with nongestational ovarian choriocarcinoma treated in Peking Union Medical College Hospital from January 1985 to October 2008. All patients' conditions were diagnosed by histopathologic examination; in 3 of them, the diagnosis was confirmed by DNA polymorphism analysis at 12 short tandem repeat loci.
Correct diagnosis was achieved in only 3 patients before initial treatment. All patients received standard multiple-drug combined chemotherapy and underwent an operation. The mean number of chemotherapy courses for each patient was 10. Of the 21 patients, 16 achieved complete remission, and 4 obtained partial remission; 1 died. In a median follow-up of 71.4 months, the 5-year overall survival rate was 79.4%.
The early diagnosis of nongestational ovarian choriocarcinoma is expected to be improved. DNA polymorphism analysis is a useful tool in determining the origin of ovarian choriocarcinoma. The prognosis is optimistic if managed with standard multiple-drug chemotherapy combined with surgical treatment.
本研究旨在探讨非妊娠性卵巢绒毛膜癌的临床特征、诊断、治疗和预后。
回顾性分析北京协和医院 1985 年 1 月至 2008 年 10 月收治的 21 例非妊娠性卵巢绒毛膜癌患者。所有患者均经组织病理学检查确诊，其中 3 例经 12 个短串联重复序列位点 DNA 多态性分析确诊。
在初始治疗前，仅 3 例患者得到正确诊断。所有患者均接受标准的多药联合化疗和手术治疗。每位患者的化疗疗程平均为 10 个。21 例患者中，16 例完全缓解，4 例部分缓解，1 例死亡。中位随访 71.4 个月，5 年总生存率为 79.4%。
非妊娠性卵巢绒毛膜癌的早期诊断有望得到改善。DNA 多态性分析是确定卵巢绒毛膜癌来源的有用工具。如果采用标准的多药化疗联合手术治疗，预后乐观。
