Morin J P, Boutelet I, Toutain H, Fillastre J P
INSERM U-295, UER de Médecine et de Pharmacie, Saint-Etienne-du-Rouvrais, France.
Pathol Biol (Paris). 1987 Nov;35(9):1215-20.
Male and female rabbits were given a I.V. bolus injection of a single 5 ml/kg dose of either ioxitalamic acid, ioxaglic acid or iohexol. Animals were killed 2 hours, 8 hours and 24 hours after the injection. One group of animals received a continuous I.V. infusion of contrast agent at a constant rate of 2.5 ml/kg/hour of four hours. Animals were killed 30 minutes after the end of the infusion. Plasma and tissue concentrations of contrast agents were assayed using an HPLC method. A pharmacokinetic study was performed after the I.V. bolus injection. This study shows that: 1) Plasma elimination half-lives were identical in males and in females as well as for all three products. This half life is about 45 minutes. The distribution volume was identical in male and females as well as for all three products and was comprised between 20% and 26% of body weight. 2) For all three contrast agents, the renal cortical concentrations are higher than in the medulla or the papilla at all the observation times. The renal cortical accumulation of contrast agents is persistent in comparison to plasma concentrations. 3) Ionic and lipophilic properties of contrast agents seem to play an important role on the renal accumulation pattern.
给雄性和雌性兔子静脉推注单剂量5 ml/kg的碘他拉酸、碘克沙酸或碘海醇。在注射后2小时、8小时和24小时处死动物。一组动物以2.5 ml/kg/小时的恒定速率静脉持续输注造影剂4小时。在输注结束后30分钟处死动物。使用高效液相色谱法测定造影剂的血浆和组织浓度。在静脉推注后进行了药代动力学研究。该研究表明：1）血浆消除半衰期在雄性和雌性以及所有三种产品中相同。该半衰期约为45分钟。分布容积在雄性和雌性以及所有三种产品中相同，占体重的20%至26%。2）对于所有三种造影剂，在所有观察时间，肾皮质浓度均高于髓质或乳头。与血浆浓度相比，造影剂在肾皮质的蓄积持续存在。3）造影剂的离子和脂溶性特性似乎对肾脏蓄积模式起重要作用。
