Furukawa T, Ueda J, Takahashi S, Sakaguchi K
Department of Radiology, Sumitomo Hospital, Osaka, Japan.
Acta Radiol. 1996 Nov;37(6):966-71. doi: 10.1177/02841851960373P2104.
To compare the dialyzability and safety of 2 types of low-osmolality contrast media administered to end-stage renal failure patients maintained on regular hemodialysis.
Of 44 CT examinations, iohexol was used in 22 and ioxaglate in the other 22. Adverse reactions and hemodynamic changes were recorded. Thirty minutes after the beginning of CT investigation, hemodialysis was commenced. Elimination rate and clearance of the contrast media were measured as indices of their dialyzability.
After 4 hours of hemodialysis, 78.4+/-6.5% of iohexol and 72.4+/-6.0% ioxaglate were eliminated. Clearance of iohexol was higher than that of ioxaglate at all sampling times. No severe hemodynamic change nor adverse reaction were observed. Minor reactions were more frequently observed in the ioxaglate group.
Iohexol, a nonionic monomeric contrast medium, is more advantageous for hemodialysis patients than ioxaglate, an ionic dimeric contrast medium.
比较两种低渗性造影剂用于维持性规律血液透析的终末期肾衰竭患者时的透析性和安全性。
44例CT检查中，22例使用碘海醇，另22例使用碘克沙醇。记录不良反应和血流动力学变化。CT检查开始30分钟后开始血液透析。测量造影剂的清除率和消除率作为其透析性指标。
血液透析4小时后，碘海醇的消除率为78.4±6.5%，碘克沙醇为72.4±6.0%。在所有采样时间点，碘海醇的清除率均高于碘克沙醇。未观察到严重血流动力学变化和不良反应。碘克沙醇组轻微反应更常见。
对于血液透析患者，非离子单体造影剂碘海醇比离子二聚体造影剂碘克沙醇更具优势。
