Xia Guojin, Hu Zhenzhen, Zhou Fuqing, Duan Wenfeng, Wang Min, Gong Honghan, He Yulin, Guan Yanxing
Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi, People's Republic of China.
Jiangxi Province Medical Imaging Research Institute, Jiangxi, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Nov 12;16:2733-2742. doi: 10.2147/NDT.S267023. eCollection 2020.
We explored changes in spontaneous brain connectivity in patients with diffuse axonal injury (DAI), assessed via functional connectivity density (FCD) tests using different frequency bands.
In all, 23 patients with DAI (17 males and 6 females) and 23 healthy controls (HCs; 17 males and 6 females) were included. Functional magnetic resonance imaging scans were performed when the participants were in a resting state and the FCD levels in three frequency bands (slow-4: 0.027-0.073 Hz, slow-5: 0.01-0.027 Hz, and typical: 0.01-0.08 Hz) were measured. In addition, Pearson's correlation coefficient was used to explore the relationship between clinical indices and brain regions with abnormal FCD values.
Compared to HCs, DAI patients had significantly greater FCD values in the right extranuclear/limbic lobe/cingulate gyrus and left limbic lobe/hippocampus/parahippocampal gyrus, and significantly lower FCD values in the left precuneus/posterior cingulate gyrus, in the slow-4 band. In the slow-5 band, the DAI patients had higher FCD values in the left inferior temporal gyrus/superior temporal gyrus, left parahippocampal gyrus/limbic lobe, left extranuclear/cingulate gyrus, and right medial frontal gyrus, and lower values in the right inferior frontal gyrus, right inferior parietal lobule, and left cingulate gyrus/limbic lobe. Moreover, compared to HCs, the values in the typical band were higher in the right extranuclear/limbic lobe/hippocampus/parahippocampal gyrus, but were significantly lower in the right precuneus/posterior cingulate gyrus and right inferior parietal lobule/supramarginal gyrus. The abnormal FCD values of these brain regions were linearly correlated with different clinical scale scores.
DAI patients had abnormal FCD values in various brain regions, indicating disruption to the brain functional network. Moreover, the values were frequency dependent. Our results provide new evidence for the pathogenesis of functional impairment and may explain the neuropathological or compensatory mechanism of the disease.
我们通过使用不同频段的功能连接密度（FCD）测试，探讨弥漫性轴索损伤（DAI）患者自发性脑连接的变化。
共纳入23例DAI患者（17例男性，6例女性）和23名健康对照者（HCs；17例男性，6例女性）。当参与者处于静息状态时进行功能磁共振成像扫描，并测量三个频段（慢4：0.027 - 0.073Hz，慢5：0.01 - 0.027Hz，以及典型频段：0.01 - 0.08Hz）的FCD水平。此外，使用Pearson相关系数探讨临床指标与FCD值异常的脑区之间的关系。
与HCs相比，DAI患者在慢4频段中，右侧核外/边缘叶/扣带回和左侧边缘叶/海马体/海马旁回的FCD值显著更高，而左侧楔前叶/后扣带回的FCD值显著更低。在慢5频段中，DAI患者在左侧颞下回/颞上回、左侧海马旁回/边缘叶、左侧核外/扣带回以及右侧额内侧回的FCD值更高，而在右侧额下回、右侧顶下小叶和左侧扣带回/边缘叶的FCD值更低。此外，与HCs相比，典型频段中右侧核外/边缘叶/海马体/海马旁回的值更高，但在右侧楔前叶/后扣带回以及右侧顶下小叶/缘上回中显著更低。这些脑区的FCD值异常与不同的临床量表评分呈线性相关。
DAI患者在多个脑区存在FCD值异常，表明脑功能网络受到破坏。此外，这些值具有频率依赖性。我们的结果为功能障碍的发病机制提供了新证据，并可能解释该疾病的神经病理或代偿机制。
