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带状疱疹或带状疱疹后神经痛患者短程和长程功能连接密度的平衡破坏：一项静息态功能磁共振成像研究

Disrupted Balance of Short- and Long-Range Functional Connectivity Density in Patients with Herpes Zoster or Postherpetic Neuralgia: A Resting-State fMRI Study.

作者信息

Jiang Jian, Hou Xiaoyan, Gu Lili, Liu Xian, Lv Huiting, Xiong Jiaxin, Kuang Hongmei, Jiang Xiaofeng, Hong Shunda

机构信息

Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People's Republic of China.

Jiangxi Medical Imaging Research Institute, Nanchang, People's Republic of China.

出版信息

J Pain Res. 2024 Aug 24;17:2753-2765. doi: 10.2147/JPR.S472349. eCollection 2024.

DOI:10.2147/JPR.S472349
PMID:39206100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352612/
Abstract

PURPOSE

This study aimed to explore the abnormal changes in short- and long-range functional connectivity density (FCD) in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN).

PATIENTS AND METHODS

Twenty HZ patients, 22 PHN patients, and 19 well-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. We used FCD mapping, a data-driven graph theory method, to investigate local and global functional connectivity patterns. Both short- and long-range FCD were calculated and compared among the PHN, HZ, and HC groups. Then, the abnormal regions were used to calculate seed-based functional connectivity. Finally, correlation analyses were performed between the altered FCD values and clinical datas.

RESULTS

Compared with HCs, HZ patients showed significantly increased long-range FCD of the bilateral cerebellum, thalamus, parahippocampal gyrus, superior temporal gyrus and lingual gyrus. HZ patients also displayed significantly decreased short-range FCD of the bilateral posterior cingulate gyrus, median cingulate/paracingulate gyri, and left precuneus. Compared with HCs, PHN patients displayed significantly decreased long-range FCD of the bilateral superior frontal gyrus and decreased short-range FCD in the bilateral posterior cingulate gyrus, median cingulate/paracingulate gyri, and precuneus. However, there was no significant difference in either long-range or short-range FCD between the PHN and HZ patients. Long-range FCD deficit areas and the right insula showed altered functional connectivity in PHN patients. Furthermore, pain duration in patients with PHN was correlated with abnormal long-range FCD.

CONCLUSION

Herpes zoster pain widely affects intra- and inter-regional functional connectivity, leading to disrupted short-range FCD and increased long-range FCD during different stages of the disease. Long-term chronic pain in PHN patients may impair the pain emotion regulation pathway. These findings could improve our understanding of the pathophysiological mechanisms of HZ and PHN and offer neuroimaging markers for HZ and PHN.

摘要

目的

本研究旨在探讨带状疱疹（HZ）和带状疱疹后神经痛（PHN）患者短程和长程功能连接密度（FCD）的异常变化。

患者与方法

20例HZ患者、22例PHN患者和19例匹配良好的健康对照者（HCs）接受了静息态功能磁共振成像扫描。我们使用FCD图谱，一种数据驱动的图论方法，来研究局部和整体功能连接模式。计算并比较了PHN、HZ和HC组的短程和长程FCD。然后，利用异常区域计算基于种子点的功能连接。最后，对FCD值改变与临床数据进行相关性分析。

结果

与HCs相比，HZ患者双侧小脑、丘脑、海马旁回、颞上回和舌回的长程FCD显著增加。HZ患者双侧后扣带回、中央旁扣带回/中央旁回和左侧楔前叶的短程FCD也显著降低。与HCs相比，PHN患者双侧额上回的长程FCD显著降低，双侧后扣带回、中央旁扣带回/中央旁回和楔前叶的短程FCD降低。然而，PHN患者和HZ患者在长程或短程FCD上均无显著差异。PHN患者长程FCD缺失区域和右侧岛叶的功能连接发生改变。此外，PHN患者的疼痛持续时间与异常长程FCD相关。

结论

带状疱疹疼痛广泛影响区域内和区域间的功能连接，导致疾病不同阶段短程FCD中断和长程FCD增加。PHN患者的长期慢性疼痛可能损害疼痛情绪调节通路。这些发现有助于提高我们对HZ和PHN病理生理机制的理解，并为HZ和PHN提供神经影像学标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/d76329dab89a/JPR-17-2753-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/60ee4a5f7acc/JPR-17-2753-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/f0680405f3cf/JPR-17-2753-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/c503630fa131/JPR-17-2753-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/3305cfe3a5b5/JPR-17-2753-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/d76329dab89a/JPR-17-2753-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/60ee4a5f7acc/JPR-17-2753-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/f0680405f3cf/JPR-17-2753-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/6b1248c3529a/JPR-17-2753-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/6437ea30d75d/JPR-17-2753-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/c503630fa131/JPR-17-2753-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/3305cfe3a5b5/JPR-17-2753-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/498d/11352612/d76329dab89a/JPR-17-2753-g0007.jpg

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