Department of Medicine, Endocrinology, Diabetes and Metabolism Unit, Ladoke Akintola University of Technology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Department of Medicine, Bowen University, Bowen University Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
Pan Afr Med J. 2020 Sep 8;37:35. doi: 10.11604/pamj.2020.37.35.25191. eCollection 2020.
Double diabetes otherwise known as hybrid diabetes, a new variant, is a combination of both type 1 and type 2 diabetes in children and adolescents. It is a diabetes variant increasing in prevalence in developed countries because of epidemic obesity among children and adolescents but extremely rare in developing countries. Double diabetes is characterized by features of both type 1 (diabetes auto-antibodies) and type 2 (obesity and insulin resistance). This occurrence can either develop on a background of type 1 diabetes due to an abnormal increase in weight from physiological growth spurt in adolescents or from high insulin dosage developing on a background of type 2 diabetes. The variant has been linked to possible increased cardiovascular risks and worsened morbidity including poor glycaemic control. Here, we report a case of a 17-year-old girl who developed features of type 2 diabetes on a background of type 1 diagnosed 6 years after T1D diagnosis.
双糖尿病，又称混合性糖尿病，是一种新的变异型，在儿童和青少年中同时存在 1 型和 2 型糖尿病。由于儿童和青少年肥胖症的流行，这种糖尿病变异型在发达国家的发病率不断上升，但在发展中国家极为罕见。双糖尿病的特征是同时存在 1 型（糖尿病自身抗体）和 2 型（肥胖和胰岛素抵抗）的特征。这种情况可能发生在 1 型糖尿病的基础上，由于青少年生理性生长突增导致体重异常增加，也可能发生在 2 型糖尿病的基础上，由于高胰岛素剂量导致体重增加。这种变异型与可能增加的心血管风险和更差的发病率有关，包括血糖控制不佳。在这里，我们报告了一例 17 岁女孩的病例，她在 1 型糖尿病诊断 6 年后出现了 1 型糖尿病的特征，表现为 2 型糖尿病。
