Gadol C L, Joshi V V, Lee E Y
Children's Hospital of New Jersey, Newark 07107.
Pediatr Pulmonol. 1987 Nov-Dec;3(6):437-9. doi: 10.1002/ppul.1950030611.
Chronic reactive bronchiolar obstruction has not been noted to occur with repeated aspiration of food materials. In this report, we describe two autopsy cases of children aged 8 years and 22 months with cerebral palsy, one with documented and treated esophageal reflux, and both with histories of repeated aspiration pneumonia. In each case, the lungs showed multiple nodules of hyalinized tissue and organized exudate obstructing the bronchiolar lumina, with multinucleated foreign body-type giant cells surrounding intraluminal vegetable particles. It is suggested that chronic bronchiolar obstruction was a significant contributing cause of respiratory insufficiency and consequent morbidity in these patients with cerebral palsy.
慢性反应性细支气管阻塞在反复误吸食物的情况下尚未见发生。在本报告中，我们描述了两例分别为8岁和22个月大的脑瘫患儿尸检病例，其中一例有记录并接受过食管反流治疗，两例均有反复发生吸入性肺炎的病史。在每例病例中，肺部均可见多个透明变性组织结节和机化性渗出物阻塞细支气管腔，腔内可见多核异物型巨细胞围绕植物颗粒。提示慢性细支气管阻塞是这些脑瘫患者呼吸功能不全及由此导致发病的一个重要原因。
