Clayer Elise, Dalseno Destiny, Kueh Andrew, Lacey Derek, Tsai Minhsuang, Arvell Elyas H, Wimmer Verena C, Bouillet Philippe
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.
Department of Medical Biology, the University of Melbourne, Melbourne, VIC 3052, Australia.
iScience. 2020 Oct 23;23(11):101726. doi: 10.1016/j.isci.2020.101726. eCollection 2020 Nov 20.
Post-transcriptional regulation mechanisms control mRNA stability or translational efficiency via ribosomes, and recent evidence indicates that it is a major determinant of the accurate levels of cytokine mRNAs. Transcriptional regulation of has been well studied and found to be important for the rapid induction of mRNA and regulation of the acute phase of inflammation, whereas study of its post-transcriptional regulation has been largely limited to the role of the AU-rich element (ARE), and to a lesser extent, to that of the constitutive decay element (CDE). We have identified another regulatory element (NRE) in the 3' UTR of and demonstrate that ARE, CDE, and NRE cooperate to efficiently downregulate expression and prevent autoimmune inflammatory diseases. We also show that excessive TNF may lead to embryonic death.
转录后调控机制通过核糖体控制mRNA的稳定性或翻译效率，最近的证据表明，它是细胞因子mRNA准确水平的主要决定因素。[具体基因名称]的转录调控已得到充分研究，发现其对于[具体基因名称]mRNA的快速诱导和炎症急性期的调节很重要，而对其转录后调控的研究主要局限于富含AU元件（ARE）的作用，在较小程度上局限于组成型衰变元件（CDE）的作用。我们在[具体基因名称]的3'UTR中鉴定出另一个调控元件（NRE），并证明ARE、CDE和NRE协同作用以有效下调[具体基因名称]的表达并预防自身免疫性炎症疾病。我们还表明，过量的肿瘤坏死因子（TNF）可能导致胚胎死亡。
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