Pace-Asciak C R, Martin J M, Corey E J
Research Institute, Hospital for Sick Children, Toronto, Canada.
Prog Lipid Res. 1986;25(1-4):625-8. doi: 10.1016/0163-7827(86)90127-x.
Evidence is presented to show that pancreatic islets of Langerhans are capable of producing hepoxilins A3 and B3 from endogenous substrates as well as 14C-labeled 12-HPETE. Both hepoxilins are active in stimulating the release of insulin from these cells in the presence of 10 mM glucose. These experiments suggest that the hepoxilins may participate as potential endogenous mediators of insulin release in islets of Langerhans.
有证据表明，胰岛能够以内源性底物以及14C标记的12-HPETE生成hepoxilins A3和B3。在10 mM葡萄糖存在的情况下，这两种hepoxilins均能刺激这些细胞释放胰岛素。这些实验表明，hepoxilins可能作为胰岛中胰岛素释放的潜在内源性介质发挥作用。
