Dabira Edgard Diniba, Soumare Harouna M, Lindsay Steven W, Conteh Bakary, Ceesay Fatima, Bradley John, Kositz Christian, Broekhuizen Henk, Kandeh Balla, Fehr Alexandra E, Nieto-Sanchez Claudia, Ribera Joan Muela, Peeters Grietens Koen, Smit Menno Roderick, Drakeley Chris, Bousema Teun, Achan Jane, D'Alessandro Umberto
Medical Research Council Unit Gambia, London School of Hygiene and Tropical Medicine, Banjul, Gambia.
Department of Biosciences, Durham University, Durham, United Kingdom.
JMIR Res Protoc. 2020 Nov 19;9(11):e20904. doi: 10.2196/20904.
With a decline in malaria burden, innovative interventions and tools are required to reduce malaria transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as a potential tool to further reduce malaria transmission, where coverage of vector control interventions is already high. However, the impact is limited in time. Combining an ACT with an endectocide treatment that is able to reduce vector survival, such as ivermectin (IVM), could increase the impact of MDA and offer a new tool to reduce malaria transmission.
The study objective is to evaluate the impact of MDA with IVM plus dihydroartemisinin-piperaquine (DP) on malaria transmission in an area with high coverage of malaria control interventions.
The study is a cluster randomized trial in the Upper River Region of The Gambia and included 32 villages (16 control and 16 intervention). A buffer zone of ~2 km was created around all intervention clusters. MDA with IVM plus DP was implemented in all intervention villages and the buffer zones; control villages received standard malaria interventions according to the Gambian National Malaria Control Program plans.
The MDA campaigns were carried out from August to October 2018 for the first year and from July to September 2019 for the second year. Statistical analysis will commence once the database is completed, cleaned, and locked.
This is the first cluster randomized clinical trial of MDA with IVM plus DP. The results will provide evidence on the impact of MDA with IVM plus DP on malaria transmission.
ClinicalTrials.gov NCT03576313; https://clinicaltrials.gov/ct2/show/NCT03576313.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/20904.
随着疟疾负担的下降,需要创新的干预措施和工具来进一步减少疟疾传播。在病媒控制干预措施覆盖率已经很高的地区,基于青蒿素的联合疗法(ACT)的大规模药物给药(MDA)已被确定为进一步减少疟疾传播的潜在工具。然而,其影响在时间上是有限的。将ACT与能够降低病媒存活率的内吸性杀虫剂治疗(如伊维菌素(IVM))相结合,可能会增加MDA的影响,并提供一种减少疟疾传播的新工具。
本研究的目的是评估在疟疾控制干预措施覆盖率高的地区,使用IVM加双氢青蒿素哌喹(DP)进行MDA对疟疾传播的影响。
该研究是在冈比亚上河区进行的一项整群随机试验,包括32个村庄(16个对照村和16个干预村)。在所有干预群组周围创建了一个约2公里的缓冲区。在所有干预村和缓冲区实施了IVM加DP的MDA;对照村根据冈比亚国家疟疾控制计划接受标准疟疾干预措施。
第一年的MDA活动于2018年8月至10月开展,第二年于2019年7月至9月开展。一旦数据库完成、清理并锁定,将开始进行统计分析。
这是首次关于IVM加DP进行MDA的整群随机临床试验。结果将为IVM加DP进行MDA对疟疾传播的影响提供证据。
ClinicalTrials.gov NCT03576313;https://clinicaltrials.gov/ct2/show/NCT03576313。
国际注册报告识别码(IRRID):DERR1-10.2196/20904。