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检测铅中毒的生化方法（作者译）

[Biochemical methods for the detection of lead poisoning (author's transl)].

作者信息

Kisser W

出版信息

Arch Toxicol. 1977 Jul 19;37(3):173-93. doi: 10.1007/BF00355487.

DOI:10.1007/BF00355487
PMID:332114
Abstract

After a short description of sources of lead poisoning a review is given of toxicity, absorption, storage and excretion of lead. Afterwards its biochemical affects--especially the influence on the biosynthesis of heme--are treated. Methods for diagnosis of lead poisoning resulting from these affects--determination of coproporphyrine and delta-aminolevulinic acid excretion in urine, erythrocyte delta-aminolevulinic acid dehydratase activity and erythrocyte protoporphyrin--are discussed in detail.

摘要

在简短描述铅中毒的来源之后，本文对铅的毒性、吸收、储存和排泄进行了综述。随后探讨了其生化影响——尤其是对血红素生物合成的影响。详细讨论了由这些影响导致的铅中毒的诊断方法——尿中粪卟啉和δ-氨基乙酰丙酸排泄量的测定、红细胞δ-氨基乙酰丙酸脱水酶活性以及红细胞原卟啉。

相似文献

1
[Biochemical methods for the detection of lead poisoning (author's transl)].检测铅中毒的生化方法（作者译）
Arch Toxicol. 1977 Jul 19;37(3):173-93. doi: 10.1007/BF00355487.
2
Lead toxicity and heme biosynthesis.铅中毒与血红素生物合成
Ann Clin Lab Sci. 1980 Sep-Oct;10(5):402-13.
3
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.射击场空气中铅导致的铅中毒。对一种有毒重金属的不寻常暴露。
Am J Med. 1977 Aug;63(2):306-12. doi: 10.1016/0002-9343(77)90246-7.
4
Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.铜铸造工人血清和红细胞中的微量元素水平以及红细胞血红素代谢的一些参数（游离原卟啉、δ-氨基-γ-酮戊酸脱水酶、δ-氨基-γ-酮戊酸尿）
Pol J Occup Med Environ Health. 1991;4(4):339-47.
5
[Use of some indicators of "effect" in subjects exposed to lead].[铅暴露受试者中某些“效应”指标的应用]
Med Lav. 1978 Jan-Feb;69(1):96-7.
6
[Biological monitoring of workers exposed to lead. Usefulness and limitations of indicators of internal dose and early biological effect].[铅暴露工人的生物监测。内剂量指标和早期生物效应的实用性与局限性]
Med Lav. 1978 Jan-Feb;69(1):4-25.
7
Long-term observation of biochemical effects of lead in human experiments.
J Clin Chem Clin Biochem. 1979 Apr;17(4):225-33. doi: 10.1515/cclm.1979.17.4.225.
8
Dose-response relationships for inorganic lead. I. Biochemical and haematological responses.无机铅的剂量-反应关系。I. 生化和血液学反应。
Int Arch Occup Environ Health. 1975 Jul 11;35(1):1-18. doi: 10.1007/BF01266323.
9
[Detection of chronic lead poisoning. Value of the assay of erythrocyte protoporphyrin].
Presse Med. 1984 Oct 6;13(35):2137-41.
10
The relevance of arguments for excluding ALAD from the recommended biological limit values in occupational exposure to inorganic lead (WHO 1980).关于将δ-氨基-γ-酮戊酸脱水酶排除在职业性接触无机铅的推荐生物限值之外的论据的相关性（世界卫生组织，1980年）
Int Arch Occup Environ Health. 1982;50(4):397-412. doi: 10.1007/BF00377836.

引用本文的文献

1
Arginase and kallikrein activities as biochemical indices of occupational exposure to lead.精氨酸酶和激肽释放酶活性作为职业性铅暴露的生化指标。
Br J Ind Med. 1981 May;38(2):175-8. doi: 10.1136/oem.38.2.175.

本文引用的文献

1
Some newer concepts of the natural derivatives of hemoglobin; general considerations; the serum bilirubin and bilirubinuria; the erythrocyte protoporphyrin.血红蛋白天然衍生物的一些新观念；一般考量；血清胆红素与胆红素尿；红细胞原卟啉。
Blood. 1946 Mar;1:99-120.
2
Tetraethyl lead poisoning.四乙基铅中毒
Br Med J. 1946 Nov 9;2(4479):681-5. doi: 10.1136/bmj.2.4479.681.
3
Porphyrin in the urine as a first symptom of leadpoisoning.尿卟啉作为铅中毒的首发症状
Acta Med Scand. 1948 Mar 10;130(1):37-44.
4
The penetration of lead through the skin.
J Ind Hyg Toxicol. 1948 Jul;30(4):256-9.
5
Contamination of Vegetation by Tetraethyl Lead.植被中的四乙基铅污染。
Science. 1962 Sep 7;137(3532):765-6. doi: 10.1126/science.137.3532.765.
6
STUDIES OF PROTOPORPHYRIN: IV. A COMPARISON OF THE ERYTHROCYTE PROTOPORPHYRIN CONCENTRATION WITH THE RETICULOCYTE PERCENTAGE UNDER EXPERIMENTAL AND CLINICAL CONDITIONS.原卟啉的研究：IV. 实验和临床条件下红细胞原卟啉浓度与网织红细胞百分比的比较
J Clin Invest. 1944 Jan;23(1):69-80. doi: 10.1172/JCI101474.
7
CONCERNING THE NATURALLY OCCURRING PORPHYRINS. IV. THE URINARY PORPHYRIN IN LEAD POISONING AS CONTRASTED WITH THAT EXCRETED NORMALLY AND IN OTHER DISEASES.关于天然存在的卟啉。IV. 铅中毒时的尿卟啉与正常排泄的及其他疾病时排泄的尿卟啉的对比
J Clin Invest. 1936 May;15(3):327-34. doi: 10.1172/JCI100783.
8
The relation of erythrocyte coproporphyrin and protoporphyrin to erythropoiesis.红细胞粪卟啉和原卟啉与红细胞生成的关系。
J Biol Chem. 1952 Feb;194(2):563-73.
9
Experimental porphyria. II. Type produced by lead, phenylhydrazine and light.
Proc Soc Exp Biol Med. 1952 Mar;79(3):463-8. doi: 10.3181/00379727-79-19413.
10
Porphyrin chromogens or precursors in urine, blood, bile, and feces.
J Lab Clin Med. 1951 Jun;37(6):831-42.