精氨酸酶和激肽释放酶活性作为职业性铅暴露的生化指标。
Arginase and kallikrein activities as biochemical indices of occupational exposure to lead.
作者信息
Chmielnicka J, Komsta-Szumska E, Szymańska J A
出版信息
Br J Ind Med. 1981 May;38(2):175-8. doi: 10.1136/oem.38.2.175.
Abstract
In a group of 60 workers occupationally exposed to lead the blood and urine lead concentrations, haematocrit, ALA-D and arginase activities, and urinary 5-aminolaevulinic acid (ALA) and coproporphyrin concentrations, and kallikrein activity were determined. Correlation coefficients of -0.78 and 0.77 for Pb-B/ALA and Pb-B/arginase were found respectively for lead concentrations above 40 microgram/dl blood, and 0.83, 0.76, 0.74, and -0.64 for Pb-U/ALA, Pb-U/Cp-U, Pb-U/kallikrein, and Pb.U/kallikrein, respectively. It seems that the increase in serum arginase activity may be indicative of liver damage while the decrease in kallikrein activity may indicate kidney damage in workers exposed to lead.
摘要
对60名职业性接触铅的工人测定了血铅和尿铅浓度、血细胞比容、δ-氨基乙酰丙酸脱水酶（ALA-D）和精氨酸酶活性、尿5-氨基乙酰丙酸（ALA）和粪卟啉浓度以及激肽释放酶活性。血铅浓度高于40微克/分升时，血铅与ALA、血铅与精氨酸酶的相关系数分别为-0.78和0.77；尿铅与ALA、尿铅与尿粪卟啉、尿铅与激肽释放酶、尿铅与激肽释放酶的相关系数分别为0.83、0.76、0.74和-0.64。接触铅的工人血清精氨酸酶活性升高可能提示肝损伤，而激肽释放酶活性降低可能提示肾损伤。
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