Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina.
Universidad de Buenos Aires, Facultad de Medicina, Departamento de Histología, Embriología, Biología Celular y Genética, C1121ABG Buenos Aires, Argentina.
Endocrinology. 2021 Feb 1;162(2). doi: 10.1210/endocr/bqaa215.
Puberty is characterized by major changes in the anatomy and function of reproductive organs. Androgen activity is low before puberty, but during pubertal development, the testes resume the production of androgens. Major physiological changes occur in the testicular cell compartments in response to the increase in intratesticular testosterone concentrations and androgen receptor expression. Androgen activity also impacts on the internal and external genitalia. In target cells, androgens signal through a classical and a nonclassical pathway. This review addresses the most recent advances in the knowledge of the role of androgen signaling in postnatal male sexual development, with a special emphasis on human puberty.
青春期的特点是生殖器官的解剖结构和功能发生重大变化。青春期前雄激素活性较低，但在青春期发育过程中，睾丸恢复雄激素的产生。睾丸细胞区室发生主要的生理变化，以应对睾丸内睾酮浓度和雄激素受体表达的增加。雄激素活性也对内外生殖器产生影响。在靶细胞中，雄激素通过经典和非经典途径发挥信号作用。本文综述了雄激素信号在出生后男性性发育中的作用的最新知识进展，特别强调了人类青春期。
