Babu Balaji, Ali Thaslima Asraf, Ochappan Thivagar, Mack John, Nyokong Tebello, Sethuraman Mathur Gopalakrishnan
Department of Chemistry, The Gandhigram Rural Institute - Deemed to be University, Tamil Nadu, 624 302, India; Institute for Nanotechnology Innovation, Department of Chemistry, Rhodes University, Makhanda, 6140, South Africa.
Department of Chemistry, The Gandhigram Rural Institute - Deemed to be University, Tamil Nadu, 624 302, India.
Photodiagnosis Photodyn Ther. 2021 Mar;33:102102. doi: 10.1016/j.pdpdt.2020.102102. Epub 2020 Nov 16.
Two thiobarbituric acid-functionalized pyrene derivatives (P1, P2) have been synthesized to explore the photophysical properties and photodynamic activity of dyes of this type. Both compounds exhibit an intense intramolecular charge transfer (ICT) band at ca. 470 nm, which is absent in the spectra of the precursor. P1 and P2 exhibit singlet oxygen generation on irradiation with light with moderate singlet oxygen yields of 0.36 and 0.32, respectively, in DMSO. P1 showed better photodynamic activity against MCF-7 cells with an IC value of 18.3 μM under illumination at 455 nm for 60 min with a Thorlabs M455L3 LED (330 mW.cm).
已合成两种硫代巴比妥酸功能化的芘衍生物（P1、P2），以探究此类染料的光物理性质和光动力活性。两种化合物在约470nm处均呈现出强烈的分子内电荷转移（ICT）带，而前体光谱中不存在该带。在二甲基亚砜（DMSO）中，P1和P2在光照下均能产生单线态氧，单线态氧产率适中，分别为0.36和0.32。在使用Thorlabs M455L3 LED（330 mW·cm）于455nm光照60分钟的条件下，P1对MCF-7细胞显示出更好的光动力活性，其IC值为18.3μM。
