膳食脂肪酸与成年人心血管疾病发病风险的关系：德黑兰血脂和血糖前瞻性研究。
Association of dietary fatty acids and the incidence risk of cardiovascular disease in adults: the Tehran Lipid and Glucose Prospective Study.
机构信息
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box 19395-4763, No. 24, Sahid-Erabi St, Yemen St, Chamran Exp, Tehran, Iran.
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
BMC Public Health. 2020 Nov 19;20(1):1743. doi: 10.1186/s12889-020-09824-w.
BACKGROUND
Considering the inconsistent available findings regarding the cardioprotective effect of dietary fatty acid composition, we prospectively examined the feasible association between the dietary fatty acids and the cardiovascular disease (CVD) incidence in framework of the population-based Tehran Lipid and Glucose Study.
METHODS
A total of 2369 participants (19-70 years, 43.5% men) without CVD at baseline (2006-2008) were included and followed-up for 6.7 years. Fatty acids' dietary intake was estimated using a 168-item semi-quantitative food frequency questionnaire. The CVD incidence risk across tertiles of dietary fatty acids was predicted via Cox proportional hazards regression models.
RESULTS
The average age and body mass index of the included population were 38.5 ± 13.3 years and 26.6 ± 4.8 kg/m at baseline. Over 6.7 years of follow-up, 79 cases of CVD were detected. The risk of CVD was lower in upper tertile of monounsaturated fatty acids, oleic acid, and docosahexaenoic acid + eicosapentaenoic acid among the tertiles. No significant associations were found between total fat, saturated and polyunsaturated fatty acids' intake, and CVD.
CONCLUSIONS
Our results suggest that the dietary fatty acid composition might affect the incidence risk of CVD within the Iranian population.
背景
考虑到饮食中脂肪酸组成对心脏保护作用的不一致研究结果，我们前瞻性地在基于人群的德黑兰血脂和血糖研究中研究了膳食脂肪酸与心血管疾病（CVD）发病率之间可能存在的关联。
方法
共纳入 2369 名基线时（2006-2008 年）无 CVD 的参与者（19-70 岁，43.5%为男性），随访 6.7 年。使用 168 项半定量食物频率问卷估计脂肪酸的膳食摄入量。通过 Cox 比例风险回归模型预测膳食脂肪酸三分位的 CVD 发病风险。
结果
纳入人群的平均年龄和体重指数分别为 38.5±13.3 岁和 26.6±4.8kg/m2。在 6.7 年的随访中，发现 79 例 CVD。在三分位中，单不饱和脂肪酸、油酸和二十二碳六烯酸+二十碳五烯酸的上三分位与 CVD 的风险较低。总脂肪、饱和脂肪和多不饱和脂肪的摄入量与 CVD 之间无显著相关性。
结论
我们的结果表明，伊朗人群的饮食脂肪酸组成可能影响 CVD 的发病风险。
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