Huminer D, Rosenfeld J B, Pitlik S D
Department of Internal Medicine C, Beilinson Medical Center, Petah Tiqva, Israel.
Rev Infect Dis. 1987 Nov-Dec;9(6):1102-8. doi: 10.1093/clinids/9.6.1102.
A search of the medical literature published since 1950 disclosed 19 cases of probable AIDS reported before the start of the current epidemic. These cases retrospectively met the Centers for Disease Control's surveillance definition of the syndrome and had a clinical course suggestive of AIDS. The reports originated from North America, Western Europe, Africa, and the Middle East. The mean age of patients was 37 years, and the ratio of male to female patients was 1.7:1. Sixteen patients had opportunistic infections(s) without Kaposi's sarcoma. The remainder had disseminated Kaposi's sarcoma. The commonest opportunistic infection was Pneumocystis carinii pneumonia. Two patients were reported to be homosexual. Three others had been living in Africa, and one patient was born in Haiti. In two instances concurrent or subsequent opportunistic infection occurred in family members. All patients died 1 month to 6 years after the initial manifestation of disease. In view of the historical data, unrecognized cases of AIDS appear to have occurred sporadically in the pre-AIDS era.
对1950年以来发表的医学文献进行检索后发现，在当前艾滋病流行开始之前，已有19例可能患艾滋病的病例报告。这些病例回顾性地符合美国疾病控制中心对该综合征的监测定义，且临床病程提示为艾滋病。这些报告来自北美、西欧、非洲和中东地区。患者的平均年龄为37岁，男女患者比例为1.7:1。16名患者发生了机会性感染但无卡波西肉瘤。其余患者患有播散性卡波西肉瘤。最常见的机会性感染是卡氏肺孢子虫肺炎。据报告有2名患者为同性恋者。另外3人曾在非洲生活，1名患者出生在海地。有两例家庭成员发生了并发或随后的机会性感染。所有患者在疾病首次出现后的1个月至6年内死亡。鉴于这些历史数据，在艾滋病出现之前的时代，似乎曾偶尔出现过未被识别的艾滋病病例。
