Key Laboratory of Solid Waste Treatment and Resource Recycle, Ministry of Education, School of Environment and Resource, Southwest University of Science and Technology, Sichuan Engineering Lab of Non-Metallic Mineral Powder Modification & High-Value Utilization, Mianyang 621010, China.
Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI, 49931, USA.
J Nanosci Nanotechnol. 2021 Jan 1;21(1):781-787. doi: 10.1166/jnn.2021.18730.
Montmorillonite was used as a carrier for the anticancer drug 5-fluorouracil (5FU). The selective loading of 5FU into the nanoconfined interlayer space of montmorillonite was achieved by rinsing off the weakly bonded 5FU from the external surface. The 5FU loading content in montmorillonite was 3.2 mass%. The intercalated 5FU was in an amorphous state and might be arranged as a roughly vertical monolayer in the interlayer space of montmorillonite. The intercalated 5FU showed a high thermal stability due to the protection of the montmorillonite layers. The release profiles of the intercalated 5FU were well fitted with the modified Korsmeyer-Peppas model. The montmorillonite exhibited a prolonged release of 5FU due to the restriction of the outward diffusion of intercalated 5FU. The 5FU/montmorillonite system has promising potential for oral administration for colonspecific delivery.
蒙脱石被用作抗癌药物 5-氟尿嘧啶（5FU）的载体。通过从外表面冲洗掉弱结合的 5FU，实现了 5FU 在纳米受限的蒙脱石层间空间中的选择性负载。蒙脱石中的 5FU 负载量为 3.2 质量%。插层的 5FU 处于无定形状态，可能在蒙脱石的层间空间中大致垂直单层排列。由于蒙脱石层的保护，插层的 5FU 表现出很高的热稳定性。插层 5FU 的释放曲线很好地符合改进的 Korsmeyer-Peppas 模型。由于插层 5FU 向外扩散的限制，蒙脱石表现出 5FU 的延长释放。5FU/蒙脱石系统具有用于结肠特异性给药的口服给药的应用潜力。
