Luo Honglin, Ji Dehui, Li Chunzhi, Zhu Yong, Xiong Guangyao, Wan Yizao
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China; School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China.
School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China.
Int J Pharm. 2016 Nov 20;513(1-2):17-25. doi: 10.1016/j.ijpharm.2016.09.004. Epub 2016 Sep 3.
Layered materials intercalated by drug molecules have attracted much attention since they exhibit improved safety and effectiveness in drug delivery. In this work, layered nanohydroxyapatite (L-nHAp) was synthesized by template method and a model anticancer drug 5-fluorouracil (5FU) was loaded by intercalation technique. The morphology and structure of L-nHAp/5FU hybrids were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). XRD and FTIR revealed the successful drug intercalation into the gallery of L-nHAp. TGA evidenced enhanced thermal stability of the drug molecules in the gallery of L-nHAp. The in vitro release experiments demonstrated that the release of 5FU from L-nHAp/5FU was slower than that from rodlike nanohydroxyapatite (R-nHAp)/5FU. Furthermore, the release of 5FU from L-nHAp/5FU hybrid could be fitted by first-order, Higuchi, and Rigter-Pappas models. It is believed that L-nHAp may be a promising carrier for anticancer drugs.
药物分子插层的层状材料因其在药物递送中表现出更高的安全性和有效性而备受关注。在本研究中，采用模板法合成了层状纳米羟基磷灰石（L-nHAp），并通过插层技术负载了模型抗癌药物5-氟尿嘧啶（5FU）。通过透射电子显微镜（TEM）、X射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）对L-nHAp/5FU杂化物的形貌和结构进行了表征。XRD和FTIR表明药物成功插层进入L-nHAp的层间。TGA证明了药物分子在L-nHAp层间的热稳定性增强。体外释放实验表明，5FU从L-nHAp/5FU中的释放比从棒状纳米羟基磷灰石（R-nHAp）/5FU中的释放慢。此外，5FU从L-nHAp/5FU杂化物中的释放可以用一级、Higuchi和Rigter-Pappas模型拟合。据信，L-nHAp可能是一种有前途的抗癌药物载体。
