Novel Bicyclic Heteroaryl Compounds as γ-Secretase Modulators for Treating Alzheimer's Disease.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1230 Peachtree Street NE, Suite 3100, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2020 Sep 4;11(11):2077-2078. doi: 10.1021/acsmedchemlett.0c00469. eCollection 2020 Nov 12.
Abstract
摘要
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本文引用的文献
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Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions.阿尔茨海默病；病理生理基础和治疗干预的综述。
Life Sci. 2020 Sep 1;256:117996. doi: 10.1016/j.lfs.2020.117996. Epub 2020 Jun 23.
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Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls.阿尔茨海默病的分子发病机制与干预策略：前景与困境
ACS Pharmacol Transl Sci. 2020 Mar 26;3(3):472-488. doi: 10.1021/acsptsci.9b00104. eCollection 2020 Jun 12.
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Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease.重新审视大脑和外周β淀粉样蛋白在阿尔茨海默病发病机制中的作用。
J Neurol Sci. 2020 Sep 15;416:116974. doi: 10.1016/j.jns.2020.116974. Epub 2020 Jun 7.
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Amyloid β-protein and beyond: the path forward in Alzheimer's disease.淀粉样β-蛋白及其他：阿尔茨海默病的未来之路。
Curr Opin Neurobiol. 2020 Apr;61:116-124. doi: 10.1016/j.conb.2020.02.003.
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Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.家族性阿尔茨海默病中致病性 Aβ的产生：新的发病机制见解和治疗意义。
Curr Opin Neurobiol. 2020 Apr;61:73-81. doi: 10.1016/j.conb.2020.01.011. Epub 2020 Feb 24.
6
Substrate recognition and processing by γ-secretase.γ-分泌酶对底物的识别与加工。
Biochim Biophys Acta Biomembr. 2020 Jan 1;1862(1):183016. doi: 10.1016/j.bbamem.2019.07.004. Epub 2019 Jul 8.
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