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Clin Epigenetics. 2019 Mar 29;11(1):56. doi: 10.1186/s13148-019-0653-x.
2
Exploring the effect of antenatal depression treatment on children's epigenetic profiles: findings from a pilot randomized controlled trial.探讨产前抑郁治疗对儿童表观遗传谱的影响：一项先导随机对照试验的结果。
Clin Epigenetics. 2019 Feb 4;11(1):18. doi: 10.1186/s13148-019-0616-2.
3
Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery.妊娠中期宫颈长非编码 RNA 的表达与分娩时的妊娠时间有关。
Epigenetics. 2018;13(7):742-750. doi: 10.1080/15592294.2018.1503490. Epub 2018 Aug 10.
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Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children.孕妇产前抑郁症状与儿童时期下丘脑-垂体-肾上腺轴相关基因 DNA 甲基化及日间皮质醇水平的相关性。
Dev Psychopathol. 2019 May;31(2):419-431. doi: 10.1017/S0954579418000056. Epub 2018 Apr 2.
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Maternal prenatal stress and placental gene expression of NR3C1 and HSD11B2: The effects of maternal ethnicity.母体产前应激与 NR3C1 和 HSD11B2 胎盘基因表达：母体种族的影响。
Psychoneuroendocrinology. 2018 Jan;87:166-172. doi: 10.1016/j.psyneuen.2017.10.019. Epub 2017 Oct 26.
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Prenatal anxiety effects: A review.产前焦虑的影响：综述
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Psychosom Med. 2018 Jan;80(1):34-41. doi: 10.1097/PSY.0000000000000517.
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Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy.行为与心理健康的产前发育起源：孕期母体应激的影响。
Neurosci Biobehav Rev. 2020 Oct;117:26-64. doi: 10.1016/j.neubiorev.2017.07.003. Epub 2017 Jul 28.
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Does maternal mental well-being in pregnancy impact the early human epigenome?孕期母亲的心理健康会影响人类早期表观基因组吗？
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Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support.童年期虐待、白细胞NR3C1的启动子甲基化及情感支持的潜在调节作用。
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孕期母体焦虑和抑郁与糖皮质激素受体基因的 DNA 甲基化。

Maternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene.

机构信息

Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA.

Division of Neonatology, Children's Hospital of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Epigenomics. 2021 Nov;13(21):1701-1709. doi: 10.2217/epi-2020-0022. Epub 2020 Nov 20.

DOI:10.2217/epi-2020-0022
PMID:33215541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8579934/
Abstract

To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (). Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. methylation was determined at four methylation sites. DNA methylation of CpG1 in the CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and methylation. We found that maternal anxiety was associated with increased CpG island shore methylation.

摘要

目的

定量分析妊娠期间焦虑和抑郁与糖皮质激素受体（）脐带血 DNA 甲基化差异的关系。方法：使用妊娠相关焦虑量表、状态-特质焦虑量表和爱丁堡产后抑郁量表分别收集妊娠焦虑、特质焦虑和抑郁症状。采用亚硫酸氢盐测序法检测四个甲基化位点的甲基化程度。结果：CpG1 位于 CpG 岛滨，出生于高妊娠焦虑（β 2.54，95%CI：0.49-4.58）和特质焦虑（β 1.68，95%CI：0.14-3.22）妇女的婴儿中，其 DNA 甲基化水平更高。与抑郁症状无显著相关性。结论：我们发现，母亲的焦虑与增加的 CpG 岛滨甲基化有关。