孕期母体焦虑和抑郁与糖皮质激素受体基因的 DNA 甲基化。
Maternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene.
机构信息
Stritch School of Medicine, Loyola University Chicago, Chicago, IL 60153, USA.
Division of Neonatology, Children's Hospital of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Epigenomics. 2021 Nov;13(21):1701-1709. doi: 10.2217/epi-2020-0022. Epub 2020 Nov 20.
Abstract
To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor (). Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. methylation was determined at four methylation sites. DNA methylation of CpG1 in the CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and methylation. We found that maternal anxiety was associated with increased CpG island shore methylation.
摘要
目的
定量分析妊娠期间焦虑和抑郁与糖皮质激素受体（）脐带血 DNA 甲基化差异的关系。方法：使用妊娠相关焦虑量表、状态-特质焦虑量表和爱丁堡产后抑郁量表分别收集妊娠焦虑、特质焦虑和抑郁症状。采用亚硫酸氢盐测序法检测四个甲基化位点的甲基化程度。结果：CpG1 位于 CpG 岛滨，出生于高妊娠焦虑（β 2.54，95%CI：0.49-4.58）和特质焦虑（β 1.68，95%CI：0.14-3.22）妇女的婴儿中，其 DNA 甲基化水平更高。与抑郁症状无显著相关性。结论：我们发现，母亲的焦虑与增加的 CpG 岛滨甲基化有关。
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