Ryan Joanne, Mansell Toby, Fransquet Peter, Saffery Richard
Department of Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, & Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
Department of Epidemiology & Preventive Medicine, School of Public Health & Preventive Medicine, Monash University, Prahran, Victoria, Australia.
Epigenomics. 2017 Mar;9(3):313-332. doi: 10.2217/epi-2016-0118. Epub 2017 Jan 31.
There is considerable interest in the potential nongenetic transmission of a suite of mental health conditions across generations, with epigenetics emerging as a candidate mediator of such effects. This review summarizes findings from 22 studies measuring candidate gene DNA methylation and seven epigenome-wide association studies of offspring epigenetic profile in women with adverse mental wellbeing measures (stress, depression or anxiety) in pregnancy. Despite some compelling evidence to suggest an association, there is a lack of reproducible findings, potentially linked to a number of limitations to this research and the field more broadly. Large cohorts with well characterized exposures across pregnancy are now needed. There is exciting potential that epigenetics may help explain some of the link between maternal wellbeing and child health outcomes, thereby informing novel interventions, but future studies must address current limitations to advance translational knowledge in this area.
跨代间一系列心理健康状况的潜在非遗传传递引发了人们的极大兴趣，表观遗传学成为这种效应的一个潜在介导因素。本综述总结了22项测量候选基因DNA甲基化的研究结果，以及7项关于孕期心理健康状况不佳（压力、抑郁或焦虑）的女性后代表观基因组特征的全表观基因组关联研究结果。尽管有一些令人信服的证据表明存在关联，但缺乏可重复的研究结果，这可能与该研究以及更广泛领域的一些局限性有关。现在需要有大量在孕期暴露特征明确的队列。表观遗传学有可能帮助解释母亲心理健康与儿童健康结果之间的一些联系，从而为新的干预措施提供依据，但未来的研究必须解决当前的局限性，以推进该领域的转化知识。
