Wolf Hanne Trap, Henriksen Tine Brink, Larsen Mads Langager, Pinborg Anja, Hegaard Hanne Kristine, Brok Jesper Sune, Huusom Lene Drasbek
Ugeskr Laeger. 2020 Nov 16;182(47).
Children born preterm have an increased risk of severe morbidity, e.g. cerebral palsy (CP), compared to children born at term. CP cannot be treated, which is why a prophylactic approach is essential, as argued in this review. Six randomised controlled trials (RCTs) have provided data on MgSO4 treatment as CP neuroprotection in preterm birth, including a new RCT from Denmark. Recently, an updated meta-analysis with trial sequential analysis detected a significant neuroprotective effect of MgSO4 treatment in preterm birth. There is now sufficient evidence, that MgSO4 treatment should be used as neuroprotection in preterm birth.
与足月儿相比，早产儿出现严重疾病（如脑瘫）的风险更高。脑瘫无法治愈，因此正如本综述所主张的，预防性措施至关重要。六项随机对照试验（RCT）提供了关于硫酸镁治疗作为早产脑瘫神经保护作用的数据，其中包括丹麦的一项新RCT。最近，一项采用试验序贯分析的更新荟萃分析发现硫酸镁治疗在早产中有显著的神经保护作用。现在有充分的证据表明，硫酸镁治疗应用于早产的神经保护。
