Starzl T E, Tzakis A, Makowka L, Banner B, Demetrius A, Ramsey G, Duquesnoy R, Griffin M
Department of Surgery, University of Pittsburgh Health Center, PA.
Transplant Proc. 1987 Dec;19(6):4492-7.
The first examples of hyperacute rejection of renal hemografts were seen almost 25 years ago when kidneys were transplanted to ABO incompatible recipients whose plasma contained antigraft isoagglutinins. Hyperacute rejection caused in sensitized recipients by lymphocytotoxic antibodies is similar in that the immune reaction triggers an acute inflammatory reaction that leads to widespread thrombotic occlusion and devascularization of the graft. The events after xenotransplantation between certain species are essentially the same. Potential strategies to avoid the precipitating antigen antibody reaction or to mitigate the resulting effector cascade are described.
肾移植超急性排斥反应的首个实例大约出现在25年前，当时将肾脏移植给了ABO血型不相容的受者，这些受者的血浆中含有抗移植同种凝集素。淋巴细胞毒性抗体在致敏受者中引起的超急性排斥反应与之相似，即免疫反应引发急性炎症反应，导致移植肾广泛血栓形成性闭塞和血管化丧失。某些物种间异种移植后的情况基本相同。本文描述了避免引发抗原抗体反应或减轻由此产生的效应级联反应的潜在策略。
