不同物种间异种移植排斥反应的机制及调控
Mechanism and modification of rejection of heterografts between divergent species.
作者信息
Giles G R, Boehmig H J, Lilly J, Amemiya H, Takagi H, Coburg A J, Hathaway W E, Wilson C B, Dixon F J, Starzl T E
出版信息
Transplant Proc. 1970 Dec;2(4):522-38.
Abstract
This study was undertaken with several specific objectives: to evaluate the role of preformed heterospecific antibodies in causing hyperacute rejection of whole organs transplanted from dogs to pigs or pigs to dogs; to see how much this abrupt rejection could be mitigated by the antibody depletion that occurs with the use of successive organs; to establish the contribution of coagulation changes to the pathogenesis of this kind of hyperacute rejection; and to determine if there were similarities between abrupt heterograft rejection and hyperacute rejection of homografts in presensitized recipients.
摘要
本研究有几个特定目标
评估预先形成的异种特异性抗体在导致从犬到猪或从猪到犬的全器官移植超急性排斥反应中的作用；观察使用连续器官时发生的抗体清除能在多大程度上减轻这种急性排斥反应；确定凝血变化在这种超急性排斥反应发病机制中的作用；以及确定在预先致敏的受体中，异种移植的急性排斥反应与同种移植的超急性排斥反应之间是否存在相似之处。
相似文献
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Mechanism and modification of rejection of heterografts between divergent species.不同物种间异种移植排斥反应的机制及调控
Transplant Proc. 1970 Dec;2(4):522-38.
2
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