Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Muscle Nerve. 2021 Feb;63(2):204-208. doi: 10.1002/mus.27125. Epub 2020 Dec 2.
Fasciculations are most commonly seen in the biceps brachii muscle in amyotrophic lateral sclerosis (ALS). In this study we have explored the association between fasciculation frequency in a single location-biceps brachii and brachialis muscles (BB), and disease burden and activity.
Sonographic muscle studies were performed in 90 ALS patients, 47 of whom were seen in subsequent follow-up. The association between fasciculations frequency at the BB and ALS Functional Rating Scale-Revised (ALSFRS-R) and manual muscle testing (MMT) scores was determined.
High fasciculation frequency at the BB, where detection rate was the highest, was associated with shorter disease duration, greater muscle thickness, higher MMT scores, and faster rate of decline in ALSFRS-R initially, and MMT subsequently.
High fasciculation frequency at the BB as determined by sonography, is associated with less impairment at time of examination, and a more active disease with a more rapid progression.
肌束震颤在肌萎缩侧索硬化症（ALS）中最常出现在肱二头肌。在这项研究中，我们探讨了单部位-肱二头肌和肱肌（BB）肌束震颤频率与疾病负担和活动之间的关系。
对 90 名 ALS 患者进行了超声肌肉研究，其中 47 名患者在后续随访中进行了检查。确定 BB 处肌束震颤频率与 ALS 功能评定量表修订版（ALSFRS-R）和徒手肌肉测试（MMT）评分之间的关系。
BB 处肌束震颤频率较高（检测率最高）与疾病持续时间较短、肌肉厚度较大、MMT 评分较高以及 ALSFRS-R 评分初始和随后的下降速度较快相关。
超声检查发现 BB 处肌束震颤频率较高与检查时的损伤程度较小以及疾病更活跃、进展更快有关。
