Martín-Ruiz Julio, Maset-Roig Rosa, Caplliure-Llopis Jordi, Villarón-Casales Carlos, Alarcón-Jiménez Jorge, de Bernardo Nieves, Proaño Belén, Menargues-Ramírez Rubén, Selvi-Sabater Pablo, de la Rubia-Ortí José Enrique
Department of Health and Functional Evaluation, Faculty of Physical Activity and Sports Sciences, Catholic University San Vicente Mártir, 46001 Valencia, Spain.
Doctoral Degree School, Catholic University San Vicente Mártir, 46001 Valencia, Spain.
Pharmaceuticals (Basel). 2025 Mar 28;18(4):497. doi: 10.3390/ph18040497.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of electrical activity and motor control at the muscular level. Therapeutic alternatives, such as the polyphenolic antioxidants curcumin and resveratrol in liposome form, or the drug dutasteride, could be effective for muscular activity. To measure the acute change in electrical muscle activation after administration of a combination of curcumin in liposomal form, resveratrol, and dutasteride in patients with ALS. Patients with bulbar and spinal ALS were selected and randomly distributed into an intervention group (IG), which received an oral combination of curcumin in liposomal form/resveratrol and dutasteride for 2 months, and a control group (CG), which received a placebo. Electrical activity to determine basal muscle activation and fasciculations was measured before and after the intervention using surface electromyography of the biceps brachii (BB), triceps brachii (TB), rectus femoris (RF), and tibialis anterior (TA). Within comparisons of pre and post-muscular variations in each group were conducted. Electrical basal activity increased only for the IG in the right ( = 0.05; g = -0.45) and left ( = 0.004; g = -0.74) hemibody muscles and also presented less variation among them after treatment in the IG. For fasciculations, there was an increase in the total activation of the upper muscles in the IG ( = 0.017; g = -0.86) and for the lower muscles in the CG ( = 0.037; g = -0.68). The pattern of muscle activation remained constant in the IG but experienced variations in the CG.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征是肌肉水平的电活动和运动控制丧失。治疗选择，如脂质体形式的多酚类抗氧化剂姜黄素和白藜芦醇，或药物度他雄胺，可能对肌肉活动有效。为了测量脂质体形式的姜黄素、白藜芦醇和度他雄胺联合给药后ALS患者肌肉电激活的急性变化。选择延髓和脊髓性ALS患者并随机分为干预组（IG），接受脂质体形式的姜黄素/白藜芦醇和度他雄胺的口服联合治疗2个月，以及对照组（CG），接受安慰剂。使用肱二头肌（BB）、肱三头肌（TB）、股直肌（RF）和胫前肌（TA）的表面肌电图在干预前后测量用于确定基础肌肉激活和肌束震颤的电活动。在每组内进行肌肉前后变化的比较。仅IG组右侧（P = 0.05；g = -0.45）和左侧（P = 0.004；g = -0.74）半侧身体肌肉的基础电活动增加，并且IG组治疗后它们之间的变化也较小。对于肌束震颤，IG组上半身肌肉的总激活增加（P = 0.017；g = -0.86），而CG组下半身肌肉的总激活增加（P = 0.037；g = -0.68）。IG组肌肉激活模式保持不变，但CG组出现了变化。
