肝素硫酸在斑马鱼中的生物合成。
Heparan Sulfate Biosynthesis in Zebrafish.
机构信息
Department of Organismal Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
出版信息
J Histochem Cytochem. 2021 Jan;69(1):49-60. doi: 10.1369/0022155420973980. Epub 2020 Nov 20.
Abstract
The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier studies in mice have demonstrated the importance of HS for embryonic development. In this review, the enzymes participating in zebrafish HS biosynthesis, along with a description of enzyme mutants available for functional studies, are presented. The consequences of the zebrafish genome duplication and maternal transcript contribution are briefly discussed as are the possibilities of CRISPR/Cas9 methodologies to use the zebrafish model system for studies of biosynthesis as well as proteoglycan biology.
摘要
肝素硫酸（HS）蛋白聚糖的生物合成发生在细胞的高尔基体隔间内，这将决定 HS 链的硫酸化模式，而这反过来又会对蛋白聚糖的生物学活性产生重大影响。早期在小鼠中的研究表明 HS 对胚胎发育很重要。在这篇综述中，介绍了参与斑马鱼 HS 生物合成的酶，以及可用于功能研究的酶突变体的描述。简要讨论了斑马鱼基因组加倍和母本转录物贡献的后果，以及 CRISPR/Cas9 方法在研究生物合成以及蛋白聚糖生物学方面用于斑马鱼模型系统的可能性。
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