加拿大人类母乳中邻苯二甲酸酯和己二酸二（2-乙基己基）酯的 GC-MS 分析：评估婴儿人群的暴露情况。
GC-MS Analysis of Phthalates and Di-(2-thylhexyl) Adipate in Canadian Human Milk for Exposure Assessment of Infant Population.
机构信息
Health Canada, Food Directorate, Bureau of Chemical Safety, Food Research Division, 251 Sir Frederick Banting Driveway, Ottawa, ON, Canada, K1A 0K9.
Health Canada, Healthy Environments and Consumer Safety Branch, Environmental Health Science and Research Bureau, 101 Tunney's Pasture Dr, AL 0201A, Ottawa, ON, Canada, K1A 0K9.
出版信息
J AOAC Int. 2021 Mar 5;104(1):98-102. doi: 10.1093/jaoacint/qsaa108.
BACKGROUND
Although more information has become available on the occurrence of phthalates and di(2-ethylhexyl) adipate (DEHA) in foods including cow's milk, information on their presence in human milk, the important and recommended sole diet for infants up to six months of age, is very limited, especially for DEHA.
OBJECTIVE
To develop a GC-MS method for simultaneous analysis of DEHA and phthalates in human milk samples and generate occurrence data for exposure assessment.
METHOD
Human milk samples were extracted with acetonitrile followed by dispersive solid-phase extraction and GC-MS analysis.
RESULTS
Among the 305 human milk samples collected from the Canadian Maternal-Infant Research on Environmental Chemicals Study, some phthalates (DHxP, BBzP, and DOP) were not detected in any of the samples, while DEHA and the other phthalates (DMP, DEP, DBP, DiBP, and DEHP) were detected at low frequencies with levels from 30.4-237 ng/g in up to 31 of the 305 human milk samples.
CONCLUSIONS
In general, DEHA and phthalates were detected at low frequencies and low levels in the 305 human milk samples.
HIGHLIGHTS
A GC-MS method based on dispersive solid phase extraction was developed for analysis of DEHA and eight phthalates in 305 human milk samples for exposure assessment.
背景
尽管关于邻苯二甲酸酯和己二酸二（2-乙基己基）酯（DEHA）在包括牛奶在内的食品中的存在情况已经有了更多的信息，但有关其在人乳中存在情况的信息却非常有限，尤其是关于 DEHA 的信息。人乳是人乳中婴儿在六个月大之前唯一重要且推荐的饮食来源。
目的
开发一种 GC-MS 方法，用于同时分析人乳样品中的 DEHA 和邻苯二甲酸酯，并生成暴露评估的发生数据。
方法
用人乳样品用乙腈提取，然后进行分散固相萃取和 GC-MS 分析。
结果
在加拿大母婴环境化学研究中收集的 305 个人乳样本中，一些邻苯二甲酸酯（DHxP、BBzP 和 DOP）在任何样本中均未检出，而 DEHA 和其他邻苯二甲酸酯（DMP、DEP、DBP、DiBP 和 DEHP）则以低频率检出，在多达 31 个人乳样本中有 30.4-237ng/g 的水平。
结论
一般来说，在 305 个人乳样本中，DEHA 和邻苯二甲酸酯以低频率和低水平检出。
重点
建立了一种基于分散固相萃取的 GC-MS 方法，用于分析 305 个人乳样本中的 DEHA 和八种邻苯二甲酸酯，以进行暴露评估。
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