Erevna Innovations Inc, Montreal, Quebec, Canada.
Aesthet Surg J. 2021 Jul 14;41(8):932-941. doi: 10.1093/asj/sjaa310.
Paradoxical adipose hyperplasia (PAH) is a rare, moderate-to-severe adverse event associated with cryolipolysis (CoolSculpting, CS).
The aim of this study was to describe the incidence, diagnosis, and treatment of PAH occurring after CS for nonsurgical fat reduction.
A multicenter evaluation of all patients who underwent CS treatment between January 2015 and December 2019 at 8 Canadian medical centers was conducted. Data abstracted included symptoms, management strategy, outcome, operator characteristics, device characteristics, patient characteristics, body region, and CS treatment details. Incidence of PAH was calculated based on the number of treatment cycles.
Our findings revealed incidence rates between 0.05% and 0.39%, which are slightly higher than the manufacturer's quoted rate of 0.025% (1 per 4000 cycles). Incidence rates at all sites were dramatically reduced by over 75% with the implementation of newer models of CS units. Of patients who developed PAH, 55% were male and 77.8% were of European ethnic origin. The majority of cases (76.9%) were associated with older models of CS units.
Development of PAH may be related to a combination of factors, including older models of CS units and applicators, as well as individual characteristics that predispose certain patients.
反常性脂肪增生（PAH）是一种罕见的、中重度不良事件，与冷冻减脂术（酷塑，CS）相关。
本研究旨在描述 CS 用于非手术减脂后发生 PAH 的发生率、诊断和治疗。
对 2015 年 1 月至 2019 年 12 月期间在加拿大 8 家医疗中心接受 CS 治疗的所有患者进行了多中心评估。提取的数据包括症状、管理策略、结果、操作人员特征、设备特征、患者特征、身体部位和 CS 治疗细节。PAH 的发生率根据治疗周期数计算。
我们的研究结果显示发生率在 0.05%至 0.39%之间，略高于制造商报告的 0.025%（每 4000 个周期 1 例）。通过使用新型 CS 设备，所有部位的发生率均降低了 75%以上。发生 PAH 的患者中，55%为男性，77.8%为欧洲裔。大多数病例（76.9%）与 CS 设备的旧型号有关。
PAH 的发生可能与多种因素有关，包括 CS 设备和应用器的旧型号，以及某些患者易患的个体特征。
