Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Transfusion. 2020 Nov;60(11):2494-2499. doi: 10.1111/trf.16010. Epub 2020 Aug 10.
During storage, the potassium level of red blood cell (RBC) components increases, especially after irradiation. Neonates are prone to hyperkalemia, for example, non-oliguric hyperkalemia, so using potassium adsorption filters during transfusion may be helpful. To overcome dilution of RBC components caused by saline priming of existing potassium adsorption filters, a downsized potassium adsorption filter for neonates (PAF-n, Kawasumi Laboratories Inc., Tokyo, Japan) was developed.
To assess the performance of PAF-n, its adsorption efficiency and RBC recovery rate were evaluated by testing pre-filtration and serial post-filtration (0-30 mL, 30-60 mL, 60-90 mL, and 90-120 mL) samples from 8 RBC components.
The average potassium adsorption rate of the PAF-n was 90.5% ± 0.78%, and never less than 89.0% in any of 8 RBC components. RBC recovery rates were 99.3% ± 1.12%.
The PAF-n showed an effective potassium ability with negligible RBC dilution.
在储存过程中，红细胞（RBC）成分的钾含量会增加，尤其是在辐照之后。例如，新生儿容易发生高钾血症，非少尿性高钾血症，因此在输血过程中使用钾吸附过滤器可能会有所帮助。为了克服现有钾吸附过滤器盐水预充导致的 RBC 成分稀释，开发了一种用于新生儿的小型钾吸附过滤器（PAF-n，日本东京川崎实验室公司）。
为了评估 PAF-n 的性能，通过测试 8 个 RBC 成分的预过滤和连续后过滤（0-30mL、30-60mL、60-90mL 和 90-120mL）样本，评估了 PAF-n 的吸附效率和 RBC 回收率。
PAF-n 的平均钾吸附率为 90.5%±0.78%，在 8 个 RBC 成分中的任何一个中都从未低于 89.0%。RBC 回收率为 99.3%±1.12%。
PAF-n 表现出有效的钾吸附能力，且 RBC 稀释可忽略不计。
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