Cid Joan, Ramiro Laia, Bertran Sílvia, Martínez Núria, Claparols Montse, Maymó Rosa M, Puig Lluís, Pla Ramon Pau
Blood Component Preparation Department, Blood and Tissue Bank, Barcelona, Spain.
Transfusion. 2008 Sep;48(9):1966-70. doi: 10.1111/j.1537-2995.2008.01776.x. Epub 2008 Jun 28.
The transfusion of red cell (RBC) bags with high amounts of potassium (K(+)) causes concern about an increased risk of cardiac arrest because of transient hyperkalemia. To prevent K(+) overload, a K(+) adsorption filter (PAF) is available for use at bedside. The aim of the present study was to analyze the efficacy in reducing K(+) load in irradiated RBC bags with this PAF.
Whole-blood (WB) bags were collected from volunteer donors on Day 0. RBC bags were prepared from WB bags on Day +1 and stored at 2 to 6 degrees C. RBC bags were irradiated on Day +14 and filtered with the PAF on Day +28, according to the manufacturers' instructions. The plasma electrolyte levels (Na(+), K(+), Cl(-), Ca(2+), and Mg(2+)) were measured at the different points during storage.
Twelve RBC bags were prepared with a final volume of 274 +/- 15 mL. On Day +28, the volume of RBC bags was 257 +/- 15 mL, and the PAF was used at a flow rate of 4 +/- 0.7 mL per minute. K(+) level after RBC bag preparation was 1.28 +/- 0.59 mmol per L. The K(+) level was 60.6 +/- 2.68 mmol per L on Day +28, just before filtration with the PAF. After filtration, the level of K(+) was 3.42 +/- 2.91 mmol per L.
This study has shown a high efficacy in reducing potassium load in irradiated RBC bags with the use of the PAF.
输注含有大量钾（K⁺）的红细胞（RBC）袋会引发对因短暂高钾血症导致心脏骤停风险增加的担忧。为防止钾过载，一种钾吸附过滤器（PAF）可在床边使用。本研究的目的是分析使用这种PAF降低辐照RBC袋中钾负荷的效果。
在第0天从志愿献血者采集全血（WB）袋。在第+1天从WB袋制备RBC袋，并在2至6℃下储存。RBC袋在第+14天进行辐照，并在第+28天根据制造商说明用PAF过滤。在储存期间的不同时间点测量血浆电解质水平（Na⁺、K⁺、Cl⁻、Ca²⁺和Mg²⁺）。
制备了12个RBC袋，最终体积为274±15 mL。在第+28天，RBC袋体积为257±15 mL，PAF以每分钟4±0.7 mL的流速使用。制备RBC袋后钾水平为1.28±0.59 mmol/L。在第+28天，即使用PAF过滤前，钾水平为60.6±2.68 mmol/L。过滤后，钾水平为3.42±2.91 mmol/L。
本研究表明使用PAF在降低辐照RBC袋中的钾负荷方面具有高效性。
