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1
Cytotoxic cellular mediators of the immune response to neoplasia: a review.肿瘤免疫反应的细胞毒性细胞介质：综述
Yale J Biol Med. 1987 Sep-Oct;60(5):409-19.
2
Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.小鼠淋巴因子激活的杀伤（LAK）细胞现象分析：效应细胞和祖细胞分化为NK样细胞和T样细胞。
J Immunol. 1987 Jun 1;138(11):3640-5.
3
VLA-6 (CDw49f) is an important adhesion molecule in NK cell-mediated cytotoxicity following autologous or allogeneic bone marrow transplantation.VLA - 6（CDw49f）是自体或异基因骨髓移植后自然杀伤细胞介导的细胞毒性中的一种重要黏附分子。
Exp Hematol. 1995 Dec;23(14):1530-4.
4
[Identification and characterization of effector lymphocytes lysing autologous tumor cells].[裂解自体肿瘤细胞的效应淋巴细胞的鉴定与表征]
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-2):1462-8.
5
Lymphokine-activated killer (LAK) cells. I. Differential recovery of LAK, natural killer cells, and cytotoxic T lymphocytes after a sublethal dose of cyclophosphamide.淋巴因子激活的杀伤细胞（LAK细胞）。I. 亚致死剂量环磷酰胺后LAK细胞、自然杀伤细胞和细胞毒性T淋巴细胞的差异恢复
J Immunol. 1986 Oct 1;137(7):2380-4.
6
Human natural killer cells account for non-MHC class I-restricted cytolysis of porcine cells.人类自然杀伤细胞介导对猪细胞的非MHC I类限制性细胞溶解作用。
Cell Immunol. 1997 Feb 1;175(2):171-8. doi: 10.1006/cimm.1996.1053.
7
[New insights into cytotoxic effector cells].[细胞毒性效应细胞的新见解]
Bull Cancer. 2005 Nov;92(11):935-43.
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Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells.细胞因子诱导的杀伤细胞肿瘤细胞识别中涉及的效应细胞的表型特征及鉴定
Exp Hematol. 1993 Dec;21(13):1673-9.
9
Tumor-specific lysis of human renal cell carcinomas by tumor-infiltrating lymphocytes: modulation of recognition through retroviral transduction of tumor cells with interleukin 2 complementary DNA and exogenous alpha interferon treatment.肿瘤浸润淋巴细胞对人肾细胞癌的肿瘤特异性裂解：通过用白细胞介素2互补DNA逆转录病毒转导肿瘤细胞和外源性α干扰素治疗调节识别。
Cancer Res. 1993 Sep 1;53(17):4020-5.
10
Human natural killer cells: a comprehensive review.人类自然杀伤细胞：全面综述。
Int J Oncol. 2005 Jul;27(1):5-47.

引用本文的文献

1
Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response.关键进展：实体瘤中的嗜酸性粒细胞浸润是一种早期且持续的炎症性宿主反应。
J Leukoc Biol. 2006 Jun;79(6):1131-9. doi: 10.1189/jlb.0106027. Epub 2006 Apr 14.
2
Immunotherapy of malignancy by in vivo gene transfer into tumors.通过向肿瘤内进行体内基因转移对恶性肿瘤进行免疫治疗。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4645-9. doi: 10.1073/pnas.90.10.4645.

本文引用的文献

1
Role of NK cells in tumour growth and metastasis in beige mice.NK细胞在米色小鼠肿瘤生长和转移中的作用。
Nature. 1980 Apr 17;284(5757):622-4. doi: 10.1038/284622a0.
2
Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.自然杀伤（NK）细胞在体内抑制实验性肿瘤转移的确凿证据。
J Immunol. 1981 Nov;127(5):1754-8.
3
Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.癌症免疫学：寻找特异性——G. H. A. 克劳斯纪念讲座
Cancer Res. 1981 Feb;41(2):361-75.
4
The differentiation and function of human T lymphocytes.人类T淋巴细胞的分化与功能。
Cell. 1980 Apr;19(4):821-7. doi: 10.1016/0092-8674(80)90072-0.
5
A severe combined immunodeficiency mutation in the mouse.小鼠中的一种严重联合免疫缺陷突变。
Nature. 1983 Feb 10;301(5900):527-30. doi: 10.1038/301527a0.
6
The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
J Exp Med. 1983 Apr 1;157(4):1149-69. doi: 10.1084/jem.157.4.1149.
7
Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells.淋巴因子激活的杀伤细胞现象。II. 前体细胞表型在血清学上与外周T淋巴细胞、记忆性细胞毒性胸腺来源淋巴细胞及自然杀伤细胞不同。
J Exp Med. 1983 Mar 1;157(3):884-97. doi: 10.1084/jem.157.3.884.
8
Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins.假定的T细胞受体多肽与免疫球蛋白之间的序列关系。
Nature. 1984;308(5955):153-8. doi: 10.1038/308153a0.
9
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.人肿瘤坏死因子：前体结构、表达及其与淋巴毒素的同源性。
Nature. 1984;312(5996):724-9. doi: 10.1038/312724a0.
10
Identification of a clonally restricted 90 kD heterodimer on two human cloned natural killer cell lines. Its role in cytotoxic effector function.在两个人类克隆的自然杀伤细胞系上鉴定出一种克隆性受限的90 kD异二聚体。其在细胞毒性效应功能中的作用。
J Exp Med. 1983 Nov 1;158(5):1547-60. doi: 10.1084/jem.158.5.1547.

肿瘤免疫反应的细胞毒性细胞介质：综述

Cytotoxic cellular mediators of the immune response to neoplasia: a review.

作者信息

Khavari P

机构信息

Yale University School of Medicine, New Haven, Connecticut.

出版信息

Yale J Biol Med. 1987 Sep-Oct;60(5):409-19.

PMID:3321723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2590351/
Abstract

Immunotherapy in the management of neoplastic disease has recently been a major focus of scientific attention. Studies in vitro and in animal systems have provided the basis for the first trials of cellular immunotherapy for neoplasia in humans. Work over the past ten years has identified several distinct populations of lymphocytes active in lysing neoplastic cells, including major histocompatibility complex (MHC)-restricted and non-restricted cytotoxic T lymphocytes (CTL), natural killer (NK) cells, the natural cell-mediated cytotoxicity (NCMC) population, and the lymphokine-activated killer (LAK) phenomenon. This paper reviews the current understanding of the distinguishing cell surface phenotypes, recognition structures, mechanisms of neoplastic target cell lysis, activation requirements, and ontogeny of each of these cell groups.

摘要

免疫疗法在肿瘤疾病治疗中的应用近来一直是科学关注的焦点。体外和动物系统研究为人类肿瘤细胞免疫疗法的首批试验提供了基础。过去十年的研究已确定了几个不同的淋巴细胞群体，它们在裂解肿瘤细胞方面具有活性，包括主要组织相容性复合体（MHC）限制和非限制的细胞毒性T淋巴细胞（CTL）、自然杀伤（NK）细胞、自然细胞介导的细胞毒性（NCMC）群体以及淋巴因子激活的杀伤（LAK）现象。本文综述了目前对这些细胞群体各自独特的细胞表面表型、识别结构、肿瘤靶细胞裂解机制、激活要求以及个体发生的理解。