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Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices - United States, 2019.破伤风类毒素、白喉类毒素和无细胞百日咳疫苗的使用:免疫实践咨询委员会更新的建议——美国,2019 年。
MMWR Morb Mortal Wkly Rep. 2020 Jan 24;69(3):77-83. doi: 10.15585/mmwr.mm6903a5.
2
Tetanus: epidemiology and Factors Associated with Death in the Departement of Tropical and infectious diseases of Donka National Hospital, Guinea.破伤风:几内亚东卡国立医院热带病与传染病科的流行病学及死亡相关因素
Med Sante Trop. 2019 Aug 1;29(3):333-336. doi: 10.1684/mst.2019.0924.
3
Functional outcome and muscle wasting in adults with tetanus.破伤风成年患者的功能结局与肌肉萎缩
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A Case of Tetanus Simulating Acute Abdomen.一例误诊为急腹症的破伤风病例。
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7
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8
[A case of acute abdomen caused by tetanus].[一例破伤风所致急腹症]
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一例伪装成急腹症的破伤风罕见病例:病例报告

An Unusual Case of Tetanus Masquerading as an Acute Abdomen: A Case Report.

作者信息

Thakur Rahul Kumar, Singh Rajshree, Nepal Sabin, Ghimire Prasanna

机构信息

B.P. Koirala Institute of Health Sciences, Department of Emergency Medicine, Dharan, Nepal.

Nepalese Army Institute of Health Sciences College of Medicine, Department of Emergency Medicine, Kathmandu, Nepal.

出版信息

Clin Pract Cases Emerg Med. 2020 Nov;4(4):599-602. doi: 10.5811/cpcem.2020.8.49073.

DOI:10.5811/cpcem.2020.8.49073
PMID:33217282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7676795/
Abstract

INTRODUCTION

Tetanus is an acute onset neurological disease that is often lethal. It has a high disease burden in low and middle-income countries. Tetanus is caused by a toxin made by spores of the bacterium Clostridium tetani, which are found in soil, dust, and animal feces. The toxin impairs the motor neurons leading to muscle stiffness. However, with the development of a toxoid vaccine, the incidence has sharply declined and is now categorized as a vaccine-preventable disease. The treatment of tetanus is primarily supportive and focuses on managing the complications until the effects of toxins resolve.

CASE REPORT

We report the case of a 67-year-old farmer who previously sustained a laceration injury approximately 45 days prior to presenting to the emergency department with abdominal pain and rigidity. After a comprehensive evaluation to rule out other items in the differential diagnoses, he was diagnosed with tetanus based on clinical symptoms and ultimately required mechanical ventilation. The patient was then managed in the intensive care unit and later made an uneventful recovery.

CONCLUSION

This case illustrates an uncommon presentation of tetanus and the latency of the infectious process. Often when patients present with atypical symptoms, it poses a diagnostic dilemma to the clinicians. Thus, it is very important to carefully elicit a history of contaminated injury. This case also highlights the importance of prophylactic vaccine in low and middle-income countries, which can reduce disease-related mortality and morbidity.

摘要

引言

破伤风是一种急性发作的神经系统疾病,常可致命。在低收入和中等收入国家,其疾病负担较重。破伤风由破伤风梭菌芽孢产生的毒素引起,这些芽孢存在于土壤、灰尘和动物粪便中。该毒素会损害运动神经元,导致肌肉僵硬。然而,随着类毒素疫苗的研发,破伤风发病率已大幅下降,如今被归类为可通过疫苗预防的疾病。破伤风的治疗主要是支持性治疗,重点是处理并发症,直至毒素作用消退。

病例报告

我们报告一例67岁农民的病例,该患者在因腹痛和腹部僵硬到急诊科就诊前约45天曾有过撕裂伤。在进行全面评估以排除鉴别诊断中的其他项目后,根据临床症状诊断为破伤风,最终需要机械通气。该患者随后在重症监护病房接受治疗,后来顺利康复。

结论

本病例说明了破伤风的罕见表现及感染过程的潜伏期。当患者出现非典型症状时,临床医生常常面临诊断难题。因此,仔细询问有无污染伤口史非常重要。本病例还凸显了低收入和中等收入国家预防性疫苗的重要性,它可降低与疾病相关的死亡率和发病率。