School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang Provence, 150001, China.
State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, Harbin, 150001, China.
Cancer Lett. 2021 Feb 28;499:49-59. doi: 10.1016/j.canlet.2020.11.007. Epub 2020 Nov 18.
Hypoxia is a feature of the solid tumor microenvironment that is associated with poor clinical outcomes in multiple tumor types. Hypoxia-induced factor-1 alpha (HIF-1α) is a master regulator of hypoxic adaption, has been demonstrated to modulate hypoxic gene expression profiling and signaling transduction networks, and is thus a potential therapeutic target. Despite hypoxic response signaling having being extensively studied, the involvement of long non-coding RNAs (lncRNAs) in the hypoxic response has become a new focus of attention. Emerging evidence has documented complex interactions between HIF-1α and lncRNAs, which contribute to the acquisition of multiple hallmarks of cancer. In this review, we focus on recent advances in the study of hypoxia and HIF-1α-regulated lncRNAs, and summarize the molecular mechanisms and functional outcomes of the interplay between lncRNAs and HIF-1α, which may provide important insights into cancer diagnosis and prognosis, enabling better control of cancer.
缺氧是实体瘤微环境的一个特征，与多种肿瘤类型的不良临床结局相关。缺氧诱导因子-1α（HIF-1α）是缺氧适应的主要调节因子，已被证明可以调节缺氧基因表达谱和信号转导网络，因此是一个潜在的治疗靶点。尽管缺氧反应信号已经得到了广泛的研究，但长非编码 RNA（lncRNA）在缺氧反应中的参与已成为新的关注焦点。新出现的证据记录了 HIF-1α 和 lncRNA 之间的复杂相互作用，这有助于获得癌症的多种特征。在这篇综述中，我们重点介绍了缺氧和 HIF-1α 调节的 lncRNA 研究的最新进展，并总结了 lncRNA 和 HIF-1α 之间相互作用的分子机制和功能结果，这可能为癌症诊断和预后提供重要的见解，并能够更好地控制癌症。
