Müller P, Dammann H G, Simon B
Medizinische Universitätsklinik Heidelberg, Gastroenterologische Abteilung.
Z Rheumatol. 1987 Sep-Oct;46(5):256-7.
In randomised crossover fashion, the gastric and duodenal tolerability of two different ibuprofen galenic formulations were directly compared in ten healthy volunteers. An endoscopic evaluation was performed after 7 and 14 days treatment. 300 mg Ibuprofen q.i.d. as pellets, as well as 600 mg Ibuprofen b.i.d. as dragees, evoked a lesion score of 1.6 +/- 0.3 and 1.7 +/- 0.4 after 7 days of treatment (n.s.). After 14 days, the lesion score under ibuprofen dragees was slightly higher (1.9 +/- 0.3) when compared with the pellet formulation (1.6 +/- 0.3). This difference did not reach statistical significance. Both ibuprofen preparations were well tolerated.
以随机交叉方式，在10名健康志愿者中直接比较了两种不同布洛芬制剂的胃和十二指肠耐受性。治疗7天和14天后进行内镜评估。每日4次服用300毫克布洛芬颗粒剂，以及每日2次服用600毫克布洛芬糖衣丸，治疗7天后的损伤评分为1.6±0.3和1.7±0.4（无统计学差异）。14天后，与颗粒剂（1.6±0.3）相比，布洛芬糖衣丸下的损伤评分略高（1.9±0.3）。这种差异未达到统计学意义。两种布洛芬制剂耐受性良好。
