Müller P, Dammann H G, Simon B
Z Rheumatol. 1986 Mar-Apr;45(2):68-70.
The effect of 5 days' treatment with indomethacin, acemethacin and proglumethacin on the gastroduodenal mucosa was endoscopically evaluated in healthy volunteers. In a randomised double-blind crossover system 16 subjects received 50 mg t.i.d. indomethacin and 60 mg t.i.d. acemethacin, and a further 16 volunteers received 50 mg t.i.d. indomethacin and 150 mg t.i.d. proglumethacin. After 5 days both proglumethacin and acemethacin caused significantly less gastroduodenal lesions than indomethacin. Possible reasons for the apparently better gastro-duodenal tolerability of both indomethacin derivatives are discussed.
在健康志愿者中，通过内镜评估了吲哚美辛、阿西美辛和丙谷美辛5天治疗对胃十二指肠黏膜的影响。在随机双盲交叉系统中，16名受试者接受每日3次、每次50 mg的吲哚美辛和每日3次、每次60 mg的阿西美辛，另外16名志愿者接受每日3次、每次50 mg的吲哚美辛和每日3次、每次150 mg的丙谷美辛。5天后，丙谷美辛和阿西美辛引起的胃十二指肠病变明显少于吲哚美辛。讨论了两种吲哚美辛衍生物胃十二指肠耐受性明显更好的可能原因。
