韩国实施乙肝疫苗普遍接种 30 年后生育年龄段女性乙肝表面抗原和抗体阳性率。

Hepatitis B surface antigen and antibody positivity among women of childbearing age after three decades of universal vaccination in South Korea.

机构信息

Department of Obstetrics and Gynecology, CHA Fertility Center Seoul Station, CHA University School of Medicine, Seoul, 04637, Republic of Korea.

Department of Obstetrics and Gynecology, CHA Fertility Center Seoul Station, CHA University School of Medicine, Seoul, 04637, Republic of Korea; Department of Preventive Medicine, Korea University College of Medicine, Seoul, 02841, Republic of Korea.

出版信息

Int J Infect Dis. 2021 Mar;104:551-555. doi: 10.1016/j.ijid.2020.11.147. Epub 2020 Nov 17.

DOI:10.1016/j.ijid.2020.11.147

PMID:33217571

Abstract

OBJECTIVES

We estimated the impact of universal hepatitis B immunization using 18-year data of women who are of childbearing age in South Korea.

METHODS

We used hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) data of 145,993 women aged 20-49 years during 2001-2018 at the Gangnam CHA Medical Center. Annual prevalences of HBsAg and anti-HBs positivity were calculated and tested for linear trend. We conducted age-period-cohort (APC) analysis to obtain period and cohort effect.

RESULTS

Overall proportion of HBsAg positivity was 3.5% (n = 5050) and anti-HBs positivity was 75.3% (n = 109,907) during the study period. HBsAg positivity percentage decreased from 5.1% in 2001 to 2.5% in 2018 (P < 0.001) while anti-HBs positivity increased from 59.9% to 75.8% (P = 0.002). Average annual percent change of HBsAg positivity was -5.9% (95% confidence interval (CI): -6.9%, -4.8%). The period and cohort RR curve identified a consistent decrease in HBsAg positivity over time and across generations.

CONCLUSIONS

We observed a concurrent decrease in HBsAg and an increase in anti-HBs seropositivity among Korean women of childbearing age, implicating success in preventing vertical transmission.

摘要

目的

我们利用韩国育龄妇女 18 年的数据估计乙型肝炎免疫的普遍影响。

方法

我们使用了 2001 年至 2018 年在江南 CHA 医疗中心年龄在 20-49 岁的 145993 名妇女的乙型肝炎表面抗原（HBsAg）和抗体（抗-HBs）数据。计算了 HBsAg 和抗-HBs 阳性的年度流行率，并对其进行了线性趋势检验。我们进行了年龄-时期-队列（APC）分析，以获得时期和队列效应。

结果

在研究期间，总 HBsAg 阳性率为 3.5%（n=5050），抗-HBs 阳性率为 75.3%（n=109907）。HBsAg 阳性率从 2001 年的 5.1%下降到 2018 年的 2.5%（P<0.001），而抗-HBs 阳性率从 59.9%增加到 75.8%（P=0.002）。HBsAg 阳性率的年平均百分比变化为-5.9%（95%置信区间（CI）：-6.9%，-4.8%）。时期和队列 RR 曲线表明，HBsAg 阳性率随着时间的推移和代际的变化持续下降。