Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, NY, USA.
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
Hum Vaccin Immunother. 2022 Nov 30;18(5):2053404. doi: 10.1080/21645515.2022.2053404. Epub 2022 Apr 4.
Hepatitis B Virus (HBV) infection is a major health issue among Asian Americans. The prevalence of chronic Hepatitis B infection in New York City is estimated to be 2.7% compared with .3% in the overall United States. The efficacy and long-term immunity of HBV vaccination in the Korean American pediatric population in Queens, NY, are not well explored. This study aimed to 1) determine the age-specific prevalence of anti-HBs seropositivity in the Korean American pediatric population and 2) assess biologic/demographic factors influencing immunologic response to HBV vaccine. We performed a retrospective chart review of patients registered to a pediatric health clinic located in Queens, NY, from October 2014 to October 2020. Out of 604 medical records of patients aged ≤18 years who received a completed series of HBV vaccines during infancy, we analyzed 91 medical records where HBV serology test (HBsAg and anti-HBs) results were available. Three out of 91 subjects were born to HBsAg-positive mothers. Eight out of 91 subjects were born in South Korea. Overall, 54.9% of subjects were anti-HBs-seropositive. The seropositive rate in the 15 to 18-years-old-age group (14.3%) was significantly lower than that in other age groups: < 1 year (100%) (p = .015), 1-4 years (52.6%) (p = .033), 5-9 years (63.3%) (p = .0034), and 10-14 years (64%) (p = .0063). The mean duration since vaccination in seropositive subjects was 96.5 ± 53.9 months, and that in seronegative subjects was 121.7 ± 64.2 months (p < .047). Gender, BMI, and foreign birth were not significant risk factors affecting the nonseroprotective status. The role of routine screening of anti-HB titers and booster vaccination in this endemic community needs to be further explored.
乙型肝炎病毒 (HBV) 感染是亚裔美国人的一个主要健康问题。据估计，纽约市慢性乙型肝炎感染的流行率为 2.7%，而全美总体流行率为 0.3%。在纽约皇后区的韩裔美国儿科人群中，HBV 疫苗的疗效和长期免疫效果尚未得到充分探索。本研究旨在：1）确定韩裔美国儿科人群中抗-HBs 血清阳性的年龄特异性流行率；2）评估影响 HBV 疫苗免疫反应的生物学/人口统计学因素。我们对位于纽约皇后区的一家儿科保健诊所登记的患者进行了回顾性病历分析，时间为 2014 年 10 月至 2020 年 10 月。在接受了婴儿期 HBV 疫苗全程接种的 604 名≤18 岁患者的医疗记录中，我们分析了 91 份可获得 HBV 血清学检测（HBsAg 和抗-HBs）结果的医疗记录。91 名患者中有 3 名母亲 HBsAg 阳性，8 名出生于韩国。总体而言，54.9%的患者抗-HBs 血清阳性。15 至 18 岁年龄组的血清阳性率（14.3%）明显低于其他年龄组：<1 岁（100%）（p=0.015）、1-4 岁（52.6%）（p=0.033）、5-9 岁（63.3%）（p=0.0034）和 10-14 岁（64%）（p=0.0063）。血清阳性患者的疫苗接种后时间平均为 96.5±53.9 个月，而血清阴性患者的疫苗接种后时间为 121.7±64.2 个月（p<0.047）。性别、BMI 和外国出生不是影响非保护状态的显著危险因素。在这个流行地区，需要进一步探讨常规筛查抗-HB 滴度和加强免疫接种的作用。
