THANC (Thyroid, Head and Neck Cancer) Foundation, 10 Union Square East, Suite 5B, New York, NY 10003, USA.
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, Mount Sinai West, 1000 10th Avenue, New York, NY 10003, USA.
Clin Imaging. 2021 Apr;72:70-74. doi: 10.1016/j.clinimag.2020.11.029. Epub 2020 Nov 14.
Nasopharyngeal carcinoma (NPC) is a rare form of squamous cell carcinoma. Primary NPC is generally treated with radiation and chemotherapy, though recurrence and distant metastases are common. Reports of noncontiguous metastasis to the middle ear and external ear canal (EAC) are rare.
Case presentation of a female patient previously treated for NPC, who developed an EAC metastasis. A literature review of all reported cases of metastatic NPC in the middle ear and EAC is also included.
A patient presenting with noncontiguous metastasis of NPC to the EAC was treated with surgical resection followed by chemotherapy and radiation. The patient successfully completed treatment and is currently alive but with suspected distant metastatic disease at 11 months following treatment.
NPC metastasis to the EAC is extremely rare. Treatment options are varied, and prognosis is generally poor. The case presented here shows better outcomes than many previous reports.
鼻咽癌（NPC）是一种罕见的鳞状细胞癌。原发性 NPC 通常采用放疗和化疗治疗，但复发和远处转移较为常见。关于中耳和外耳道（EAC）非连续性转移的报道较为罕见。
报告了一例曾接受 NPC 治疗的女性患者发生 EAC 转移的病例。同时对所有报道的中耳和 EAC 转移性 NPC 病例进行了文献回顾。
一名患者出现 NPC 非连续性转移至 EAC，经手术切除后辅以化疗和放疗。患者成功完成治疗，目前仍存活，但在治疗后 11 个月时疑似出现远处转移疾病。
NPC 转移至 EAC 极为罕见。治疗选择多种多样，预后通常较差。本病例的结果优于许多先前的报告。
