儿童和青少年的沉思思维：候选基因的简要综述。
Rumination thinking in childhood and adolescence: a brief review of candidate genes.
机构信息
Sigmund Freud University, Ripa di Porta Ticinese 77, 20143 Milano, Italy.
Sigmund Freud University, Ripa di Porta Ticinese 77, 20143 Milano, Italy; "Studi Cognitivi" Cognitive psychotherapy school and research center, Foro Buonaparte 57, 20121 Milano; London South Bank University, Department of Psychology, 03 Borough Rd, London SE1 0AA, UK.
出版信息
J Affect Disord. 2021 Feb 1;280(Pt A):197-202. doi: 10.1016/j.jad.2020.11.008. Epub 2020 Nov 7.
BACKGROUND
rumination has been reported as a cognitive vulnerability factor in adolescent and adult depression. The present brief review aimed at summarizing the results of the genetic studies that investigate the candidate genes for rumination in children and adolescents.
METHODS
bibliographic research was conducted on PubMed and Science Direct from their inception to February 2020. The search terms used were: 'rumination, ruminative thinking, repetitive thinking and 'gene, gen*'.
RESULTS
eight studies were identified. Results suggest that variations in the 5-HTTLPR and BDNF genes may contribute to the tendency to ruminate, modelling the relationship between life stress and rumination.
LIMITATIONS
the interpretation of these results is limited by the sample sizes of the selected studies, the study designs, and the heterogeneity of the instruments assessing rumination.
CONCLUSIONS
these findings partially support the notion that variation in in the 5-HTTLPR and BDNF genes is associated with biological sensitivity to rumination.
背景
反刍已被报道为青少年和成年抑郁症的认知脆弱因素。本简要综述旨在总结候选基因在儿童和青少年反刍研究中的遗传研究结果。
方法
从建库到 2020 年 2 月，在 PubMed 和 Science Direct 上进行文献检索。使用的检索词是：“反刍、沉思性思维、重复性思维和“基因、gen*”。
结果
确定了八项研究。结果表明，5-HTTLPR 和 BDNF 基因的变异可能有助于反刍的倾向，为生活压力与反刍之间的关系建模。
局限性
这些结果的解释受到所选研究的样本量、研究设计以及评估反刍的工具的异质性的限制。
结论
这些发现部分支持了这样一种观点，即 5-HTTLPR 和 BDNF 基因的变异与对反刍的生物学敏感性有关。
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