Yu Jie, Tu Mingqi, Shi Yan, Liu Yingjun, He Xiaofen, Qiu Fanghui, Xu Yunyun, Sun Ruohan, Jiang Yongliang, Fang Jianqiao
Department of Acupuncture and Massage, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine.
Department of Neurobiology and Acupuncture Research, the Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.
Medicine (Baltimore). 2020 Nov 20;99(47):e23283. doi: 10.1097/MD.0000000000023283.
BACKGROUND: Postherpetic neuralgia (PHN) is the most common complication and sequela of herpes zoster (HZ) that greatly affects the life and emotional experience of patients. Acupuncture therapy has been confirmed as an effective and safe treatment for PHN. Several systematic reviews (SRs) and meta-analysis (MAs) have reported the evidence of acupuncture therapy for treating PHN. However, the evidence has not been systematically synthesized. This overview aims to synthesize and assess the reliability of evidence generated from these SRs and MAs of acupuncture therapy for PHN. METHODS: We will conduct a systematic search of the China Biology Medicine (CBM), VIP database, Wangfang database, China National Knowledge Infrastructure (CNKI), Pubmed, Cochrane Library, Excerpt Medical Database (Embase), and Web of Science to identify eligible SRs and MAs, from their inception to October 31, 2020. We will use Assessment of Multiple Systematic Reviews-2 (AMSTAR2) for methodological quality assessment, Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for report quality assessment, Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) for the quality of evidence assessment, and ROBIS for the bias assessment. Our reviewers will conduct systematic reviews, qualification evaluation, data extraction, methodological quality, and evidence quality screening in pairs. The outcomes include pain intensity, Quality of life (QoL), Hamilton Anxiety Scale (HAMA), Global impression, and adverse events. All the extracted data will be provided in tabular form to summarize characteristics of each review. The evidence will be a narrative synthesis of the type and content of the intervention and the results reported. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSIONS: This overview will provide comprehensive evidence of acupuncture therapy for patients with PHN. ETHICS AND DISSEMINATION: This review will not involve private information of participants, so the ethical approval will not be required. The results will be disseminated in a peer-reviewed journal or conference presentation. Important protocol modifications will be updated on PROSPERO. PROSPERO REGISTRATION NUMBER: CRD42020178738.
背景：带状疱疹后神经痛（PHN）是带状疱疹（HZ）最常见的并发症和后遗症，严重影响患者的生活和情感体验。针灸疗法已被确认为治疗PHN的一种有效且安全的方法。多项系统评价（SRs）和荟萃分析（MAs）报告了针灸疗法治疗PHN的证据。然而，这些证据尚未得到系统的综合。本概述旨在综合和评估这些关于针灸疗法治疗PHN的SRs和MAs所产生证据的可靠性。 方法：我们将对中国生物医学文献数据库（CBM）、维普数据库、万方数据库、中国知网、PubMed、考克兰图书馆、荷兰医学文摘数据库（Embase）和科学引文索引数据库进行系统检索，以识别从建库至2020年10月31日符合条件的SRs和MAs。我们将使用多重系统评价评估工具2（AMSTAR2）进行方法学质量评估，采用系统评价和荟萃分析报告规范（PRISMA）进行报告质量评估，运用推荐分级、评估、制定与评价（GRADE）进行证据质量评估，并用系统评价偏倚风险评估工具（ROBIS）进行偏倚评估。我们的评审人员将成对进行系统评价、资格评估、数据提取、方法学质量和证据质量筛选。结局指标包括疼痛强度、生活质量（QoL）、汉密尔顿焦虑量表（HAMA）、整体印象和不良事件。所有提取的数据将以表格形式呈现，以总结每项评价的特征。证据将是对干预类型和内容以及所报告结果的叙述性综合。 结果：本研究结果将发表在同行评审期刊上。 结论：本概述将为PHN患者提供针灸疗法的全面证据。 伦理与传播：本综述不涉及参与者的私人信息，因此无需伦理批准。结果将在同行评审期刊或会议报告中传播。重要的方案修改将在国际前瞻性系统评价注册库（PROSPERO）上更新。 PROSPERO注册号：CRD42020178738。
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