Weiss Y A, Fournier V, Pannier B, Laurent S, Safar M E
Diagnosis Center, Broussais Hospital, Paris.
Acta Cardiol. 1987;42(5):329-37.
The hemodynamic changes caused by ketanserin, an anti-hypertensive agent with S2-serotonergic receptor and alpha 1-adrenoceptor blocking properties, are reviewed in patients with essential hypertension. The hemodynamic profile associates a decrease in total peripheral resistance, an unchanged cardiac output, and a modest reflex cardiac stimulation. Whether the drug reverses the other hemodynamic abnormalities of essential hypertension, such as reduced arterial and venous compliances and increased cardiac mass, remains largely unknown. Evaluation of the changes in arterial and venous systems will be important in the view that the pharmacological profile of ketanserin could be involved in the modifications of the arterial wall observed in hypertension and atherosclerosis.
对原发性高血压患者中酮色林（一种具有 S2 - 血清素能受体和α1 - 肾上腺素能受体阻断特性的抗高血压药物）所引起的血流动力学变化进行了综述。其血流动力学特征表现为总外周阻力降低、心输出量不变以及适度的反射性心脏刺激。该药物是否能逆转原发性高血压的其他血流动力学异常，如动脉和静脉顺应性降低以及心脏质量增加，在很大程度上仍不清楚。鉴于酮色林的药理特性可能参与了在高血压和动脉粥样硬化中观察到的动脉壁改变，评估动脉和静脉系统的变化将具有重要意义。
