University of Medicine and Pharmacy "Victor Babes" Timisoara.
Med Ultrason. 2021 Feb 18;23(1):7-14. doi: 10.11152/mu-2688. Epub 2020 Oct 8.
Nonalcoholic Fatty Liver Disease (NAFLD) is increasing in frequency in daily practice and evaluation of liver steatosis, fibrosis and inflammation severity are essential for prognosis assessment. The aim was to evaluate the usefulnessof a new liver steatosis quantification system - Ultrasound-Guided Attenuation Parameter (UGAP) from General Electric Healthcare, using Controlled Attenuation Parameter (CAP) as the reference method.
179 consecutive subjects, in whom liver steatosis was assessed in the same session using UGAP, implemented on LOGIQ E10 system (GE Healthcare), and CAP (FibroScan, EchoSens). To discriminate between steatosis stages by CAP, we used the cut-offs recommended by the manufacturer: S1 (mild) - 230 dB/m, S2 (moderate) - 275 dB/m, S3 (severe) - 300 dB/m.
We classified our cohort by means of CAP into the following groups: S0 (no steatosis): 48/176 (27.2%), S1 (mild): 56/176 (31.6%), S2 (moderate): 14/176 (7.3%) and S3 (severe): 59/176 (33.9%). The mean UGAP values increased with the steatosis grade and for each group were the following: S0: 198.3±25.7 dB/m, S1: 216.86±26.3 dB/m, S2: 237.79±26.3 dB/m, and S3: 270.8±31.62 dB/m respectively (p<0.001). A very good positive correlation was found between UGAP and CAP values (r=0.73, p<0.0001). The best cut-off values for predicting different grades of liver steatosis using CAP as the reference were: S1 - 192.5 dB/m (AUC 0.83); S2 - 231 dB/m (AUC 0.90) and S3 - 248 dB/m (AUC 0.91).
UGAP seems to be a good method for liver steatosis quantification and correlates strongly with CAP values.
非酒精性脂肪性肝病（NAFLD）在日常实践中发病率不断增加，因此评估肝脏脂肪变性、纤维化和炎症严重程度对于预后评估至关重要。本研究旨在评估一种新的肝脏脂肪变性定量系统——通用电气医疗保健公司的超声衰减参数（UGAP）的实用性，以受控衰减参数（CAP）作为参考方法。
179 例连续患者在同一次检查中使用 LOGIQ E10 系统（GE 医疗保健）上的 UGAP 和 CAP（FibroScan，EchoSens）评估肝脏脂肪变性。为了根据 CAP 区分脂肪变性阶段，我们使用了制造商推荐的截止值：S1（轻度）-230 dB/m，S2（中度）-275 dB/m，S3（重度）-300 dB/m。
我们根据 CAP 将我们的队列分为以下组别：S0（无脂肪变性）：48/176（27.2%），S1（轻度）：56/176（31.6%），S2（中度）：14/176（7.3%）和 S3（重度）：59/176（33.9%）。随着脂肪变性程度的增加，UGAP 的平均值也增加，每个组的平均值分别为：S0：198.3±25.7 dB/m，S1：216.86±26.3 dB/m，S2：237.79±26.3 dB/m，S3：270.8±31.62 dB/m（p<0.001）。UGAP 值与 CAP 值之间存在非常好的正相关关系（r=0.73，p<0.0001）。使用 CAP 作为参考，预测不同等级肝脂肪变性的最佳截断值分别为：S1-192.5 dB/m（AUC 0.83）；S2-231 dB/m（AUC 0.90）和 S3-248 dB/m（AUC 0.91）。
UGAP 似乎是一种很好的肝脏脂肪变性定量方法，与 CAP 值密切相关。
