Biris Andreas I, Karamatzanis Ioannis, Biri Despoina, Biris Ioannis A, Maravegias Nikolaos
Clinical Teaching Fellow, Southend University Hospital, Mid and South Essex National Health Service (NHS) Foundation Trust, Southend, GBR.
Internal Medicine, Basildon University Hospital, Basildon, GBR.
Cureus. 2024 Oct 22;16(10):e72087. doi: 10.7759/cureus.72087. eCollection 2024 Oct.
We conducted a comprehensive literature review to evaluate the efficacy of combining two-dimensional shear wave elastography (2D-SWE) and ultrasound-guided attenuation parameter (UGAP) in assessing the risk of progressive metabolic dysfunction-associated steatohepatitis (MASH). This narrative review explores the applications of liver ultrasound in diagnosing metabolic liver diseases, focusing on recent advancements in diagnostic techniques for steatotic liver disease (SLD). Liver ultrasound can detect a spectrum of SLD manifestations, from metabolic dysfunction-associated liver disease (MASLD) to fibrosis and cirrhosis. It is also possible to identify inflammation, hepatitis, hepatocellular carcinoma (HCC), and various other liver lesions. Innovative ultrasound applications, including elastography and UGAP, can significantly enhance the diagnostic capabilities of ultrasound in accurately interpreting liver diseases. Understanding the pathogenesis of liver diseases requires a thorough analysis of their etiology and progression in order to develop sound diagnostic and therapeutic approaches. Chronic liver diseases (CLD) vary in origin, with MASLD affecting approximately 20-25% of the general population. The insidious progression of CLD from inflammation to fibrosis and cirrhosis underscores the need for effective early detection methods. This review aims to highlight the evolving role of non-invasive ultrasound-based diagnostic tests in the early detection and staging of liver diseases. By synthesizing current evidence, we aim to provide an updated perspective on the utility of advanced ultrasound techniques in redefining the diagnostic landscape for metabolic liver diseases.
我们进行了一项全面的文献综述，以评估二维剪切波弹性成像（2D-SWE）和超声引导下衰减参数（UGAP）相结合在评估进行性代谢功能障碍相关脂肪性肝炎（MASH）风险方面的疗效。本叙述性综述探讨了肝脏超声在诊断代谢性肝病中的应用，重点关注脂肪性肝病（SLD）诊断技术的最新进展。肝脏超声可以检测从代谢功能障碍相关肝病（MASLD）到纤维化和肝硬化等一系列SLD表现。还能够识别炎症、肝炎、肝细胞癌（HCC）以及各种其他肝脏病变。包括弹性成像和UGAP在内的创新性超声应用，可以显著提高超声在准确解读肝脏疾病方面的诊断能力。了解肝脏疾病的发病机制需要对其病因和进展进行全面分析，以便制定合理的诊断和治疗方法。慢性肝病（CLD）的起源各不相同，MASLD影响着约20%-25%的普通人群。CLD从炎症到纤维化和肝硬化的隐匿进展凸显了有效早期检测方法的必要性。本综述旨在强调基于超声的非侵入性诊断测试在肝脏疾病早期检测和分期中不断演变的作用。通过综合现有证据，我们旨在就先进超声技术在重新定义代谢性肝病诊断格局方面的实用性提供一个最新的观点。
