Denner Joachim
Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.
Transl Oncol. 2021 Jan;14(1):100941. doi: 10.1016/j.tranon.2020.100941. Epub 2020 Nov 19.
Many tumour cells express on their surface proteins of endogenous retroviruses (ERVs) and there are suggestions to use these retroviral antigens as target for anti-tumour vaccines. However, until now there is no convincing data showing that this strategy works, in contrast, there are considerations suggesting that this strategy may be harmful if applied.
许多肿瘤细胞在其表面表达内源性逆转录病毒(ERV)的蛋白质,有人建议将这些逆转录病毒抗原用作抗肿瘤疫苗的靶点。然而,到目前为止,没有令人信服的数据表明这种策略有效,相反,有一些考虑因素表明,如果应用这种策略可能是有害的。