在人类肿瘤中表达的内源性逆转录病毒不能用作抗肿瘤疫苗的靶点。
Endogenous retroviruses expressed in human tumours cannot be used as targets for anti-tumour vaccines.
作者信息
Denner Joachim
机构信息
Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany.
出版信息
Transl Oncol. 2021 Jan;14(1):100941. doi: 10.1016/j.tranon.2020.100941. Epub 2020 Nov 19.
Abstract
Many tumour cells express on their surface proteins of endogenous retroviruses (ERVs) and there are suggestions to use these retroviral antigens as target for anti-tumour vaccines. However, until now there is no convincing data showing that this strategy works, in contrast, there are considerations suggesting that this strategy may be harmful if applied.
摘要
许多肿瘤细胞在其表面表达内源性逆转录病毒（ERV）的蛋白质，有人建议将这些逆转录病毒抗原用作抗肿瘤疫苗的靶点。然而，到目前为止，没有令人信服的数据表明这种策略有效，相反，有一些考虑因素表明，如果应用这种策略可能是有害的。
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