内源性逆转录病毒在受刺激的小鼠淋巴细胞中的表达。一个控制有缺陷病毒丝裂原诱导的新基因座的鉴定。
Endogenous retrovirus expression in stimulated murine lymphocytes. Identification of a new locus controlling mitogen induction of a defective virus.
作者信息
Stoye J P, Moroni C
出版信息
J Exp Med. 1983 May 1;157(5):1660-74. doi: 10.1084/jem.157.5.1660.
Abstract
Germ line DNA from all strains of mice contains numerous endogenous retroviruses. One of these viruses, a virus with xenotropic host range is induced from lymphocytes of most strains by treatment with B cell mitogens. Virus induction is amplified by 5-bromo-2'-deoxyuridine (BrdU) treatment. We report here studies of the genetic control of retrovirus induction from lymphocytes in crosses between BALB/cTif mice and noninducible 129/Rrj mice. We identify a novel locus, Bdv-1, which controls the expression of a reverse transcriptase-positive, defective retrovirus in BALB/cTif lymphocytes. In addition, we confirm previous reports that xenotropic virus is controlled by a locus, Bxv-1, mapping to chromosome 1. The two loci are nonlinked and respond differently to inducing stimuli. Bxv-1 is induced mainly by BrdU and only marginally by mitogen; in contrast, Bdv-1 is induced by mitogen and BrdU has little effect. The induction of these two loci is discussed with respect to B cell differentiation.
摘要
所有小鼠品系的生殖系DNA都含有大量内源性逆转录病毒。其中一种病毒，一种具有嗜异性宿主范围的病毒，可通过用B细胞有丝分裂原处理从大多数品系的淋巴细胞中诱导产生。用5-溴-2'-脱氧尿苷（BrdU）处理可增强病毒诱导。我们在此报告了对BALB/cTif小鼠与非诱导性129/Rrj小鼠杂交后代淋巴细胞中逆转录病毒诱导的遗传控制研究。我们鉴定出一个新的基因座Bdv-1，它控制BALB/cTif淋巴细胞中一种逆转录酶阳性的缺陷型逆转录病毒的表达。此外，我们证实了先前的报道，即嗜异性病毒由位于1号染色体上的基因座Bxv-1控制。这两个基因座不连锁，对诱导刺激的反应也不同。Bxv-1主要由BrdU诱导，仅轻微受有丝分裂原诱导；相反，Bdv-1由有丝分裂原诱导，BrdU影响很小。本文结合B细胞分化对这两个基因座的诱导情况进行了讨论。
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