Department of Nephrology and Renal Transplant Medicine, Medanta - The Medicity, Gurguram, Haryana, India.
Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Transpl Infect Dis. 2021 Jun;23(3):e13523. doi: 10.1111/tid.13523. Epub 2020 Dec 2.
Histoplasmosis is an invasive mycosis caused by fungus Histoplasma capsulatum. Clinical features of histoplasmosis are often nonspecific, but patients with disseminated infection may present with severe manifestations posing an increasing threat to patients with various immunocompromised conditions. It is often misdiagnosed as tuberculosis in endemic regions leading to high mortality. There is under-reporting of histoplasmosis in solid organ transplant from India undermining its actual incidence and impact. As a result of the potentially fatal nature of the disease, careful evaluation with tissue diagnosis is recommended. We present a series of five cases of disseminated histoplasmosis in renal transplant recipients from our centre, highlighting its significance as differential diagnosis in this population. To our knowledge, this is the largest case series reported from India in renal transplant patients.
组织胞浆菌病是一种由荚膜组织胞浆菌引起的侵袭性真菌病。组织胞浆菌病的临床特征通常是非特异性的，但播散性感染的患者可能出现严重的表现，对各种免疫功能低下的患者构成越来越大的威胁。在流行地区，它常被误诊为结核病，导致死亡率很高。印度实体器官移植中组织胞浆菌病的报告不足，削弱了其实际发病率和影响。由于该病具有潜在的致命性，建议进行仔细的组织诊断评估。我们在中心报告了一系列 5 例肾移植受者的播散性组织胞浆菌病，强调了其在该人群中的鉴别诊断意义。据我们所知，这是印度在肾移植患者中报告的最大病例系列。
