Clinical and Population Health Research PhD Program, Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA.
Aging Ment Health. 2021 Oct;25(10):1903-1912. doi: 10.1080/13607863.2020.1849021. Epub 2020 Nov 23.
To longitudinally examine the latent statuses of depressive symptoms and their association with cognitive impairment in older U.S. nursing home (NH) residents.
Using Minimum Data Set 3.0, newly-admitted, long-stay, older NH residents with depression in 2014 were identified ( = 88,532). Depressive symptoms (Patient Health Questionnaire-9) and cognitive impairment (Brief Interview of Mental Status) were measured at admission and 90 days. Latent transition analysis was used to examine the prevalence of and the transition between latent statuses of depressive symptoms from admission to 90 days, and the association of cognitive impairment with the statuses at admission.
Four latent statuses of depressive symptoms were identified: '' (prevalence at admission: 17.3%; 90 days: 13.6%), '' (20.0%; 19.5%), '' (27.4%; 25.7%), and '' (35.3%; 41.2%). Most residents remained in the same status from admission to 90 days. Compared to residents who were cognitively intact, those with moderate impairment were more likely to be in '' and '' statuses; those with severe impairment had lower odds of belonging to '', '', and '' statuses.
By addressing the longitudinal changes in the heterogeneous depressive symptoms and the role of cognitive impairment, findings have implications for depression management in older NH residents.
纵向探讨老年美国养老院(NH)居民抑郁症状的潜在状态及其与认知障碍的关系。
使用最小数据集 3.0,确定了 2014 年新入院、长期住院、患有抑郁症的老年 NH 居民(n=88532)。在入院时和 90 天时测量抑郁症状(患者健康问卷-9)和认知障碍(简要精神状态访谈)。采用潜在转变分析,从入院到 90 天,检查抑郁症状潜在状态的流行率和转变,以及认知障碍与入院时状态的关系。
确定了抑郁症状的四个潜在状态:“无症状”(入院时的流行率:17.3%;90 天:13.6%)、“轻度”(20.0%;19.5%)、“中度”(27.4%;25.7%)和“重度”(35.3%;41.2%)。大多数居民从入院到 90 天保持相同的状态。与认知完好的居民相比,中度受损的居民更有可能处于“无症状”和“轻度”状态;严重受损的居民属于“无症状”、“轻度”和“中度”状态的可能性较低。
通过解决异质抑郁症状的纵向变化和认知障碍的作用,研究结果对老年 NH 居民的抑郁管理具有重要意义。